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Increased matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio in smokers with airway hyperresponsiveness and accelerated lung function decline

BACKGROUND: Airway hyperresponsiveness (AHR) is associated with airway inflammation and a rapid decline in lung function and is a predictor of future risk of COPD among smokers. Alveolar macrophages (AMs) from patients with COPD release a greater amount of matrix metalloproteinase (MMP)-9. We hypoth...

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Detalles Bibliográficos
Autores principales:	Lo, Chun-Yu, Huang, Hung-Yu, He, Jung-Ru, Huang, Tzu-Ting, Heh, Chih-Chen, Sheng, Te-Fang, Chung, Kian Fan, Kuo, Han-Pin, Wang, Chun-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903494/ https://www.ncbi.nlm.nih.gov/pubmed/29692608 http://dx.doi.org/10.2147/COPD.S161257

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