Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy

Activation of the amino acid starvation response (AAR) increases lifespan and acute stress resistance as well as regulates inflammation. However, the underlying mechanisms remain unclear. Here, we show that activation of AAR pharmacologically by Halofuginone (HF) significantly inhibits production of...

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Detalles Bibliográficos
Autores principales: Battu, Srikanth, Afroz, Sumbul, Giddaluru, Jeevan, Naz, Saima, Huang, Weishan, Khumukcham, Saratchandra Singh, Khan, Rafiq Ahmad, Bhat, Saleem Yousuf, Qureshi, Insaf Ahmed, Manavathi, Bramanandam, Khan, Aleem Ahmed, August, Avery, Hasnain, Seyed Ehtesham, Khan, Nooruddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903674/
https://www.ncbi.nlm.nih.gov/pubmed/29621237
http://dx.doi.org/10.1371/journal.pbio.2005317

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