Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs

Arginase inhibition exhibits beneficial effects in vascular endothelial and smooth muscle cells. In human aortic smooth muscle cells (hAoSMCs), native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that is involved in the pathogenesis of cardiovascular diseases. Theref...

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Detalles Bibliográficos
Autores principales: Koo, Bon-Hyeock, Yi, Bong-Gu, Jeong, Myeong-Seon, Kwon, Seung-Hea, Hoe, Kwang-Lae, Kwon, Young-Guen, Won, Moo-Ho, Kim, Young-Myeong, Ryoo, Sungwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903817/
https://www.ncbi.nlm.nih.gov/pubmed/29391541
http://dx.doi.org/10.1038/emm.2017.254

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