Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo

We recently reported that adeno-associated virus serotype 1 (AAV1) transduction of murine nigral dopaminergic (DA) neurons with constitutively active ras homolog enriched in brain with a mutation of serine to histidine at position 16 [Rheb(S16H)] induced the production of neurotrophic factors, resul...

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Detalles Bibliográficos
Autores principales: Kim, Sehwan, Moon, Gyeong Joon, Oh, Yong-Seok, Park, Jungha, Shin, Won-Ho, Jeong, Jae Yeong, Choi, Kwang Shik, Jin, Byung Kwan, Kholodilov, Nikolai, Burke, Robert E, Kim, Hyung-Jun, Ha, Chang Man, Lee, Seok-Geun, Kim, Sang Ryong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903818/
https://www.ncbi.nlm.nih.gov/pubmed/29422542
http://dx.doi.org/10.1038/emm.2017.261

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