VEGF-C promotes the development of lymphatics in bone and bone loss

Patients with Gorham-Stout disease (GSD) have lymphatic vessels in their bones and their bones gradually disappear. Here, we report that mice that overexpress VEGF-C in bone exhibit a phenotype that resembles GSD. To drive VEGF-C expression in bone, we generated Osx-tTA;TetO-Vegfc double-transgenic...

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Detalles Bibliográficos
Autores principales: Hominick, Devon, Silva, Asitha, Khurana, Noor, Liu, Ying, Dechow, Paul C, Feng, Jian Q, Pytowski, Bronislaw, Rutkowski, Joseph M, Alitalo, Kari, Dellinger, Michael T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903859/
https://www.ncbi.nlm.nih.gov/pubmed/29620526
http://dx.doi.org/10.7554/eLife.34323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903859/
https://www.ncbi.nlm.nih.gov/pubmed/29620526
http://dx.doi.org/10.7554/eLife.34323

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