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IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

Insulin-like growth factor-I receptor (IGF-IR) preferentially regulates the long-term IGF activities including growth and metabolism. Kinetics of ligand-dependent IGF-IR endocytosis determines how IGF induces such downstream signaling outputs. Here, we find that the insulin receptor substrate (IRS)−...

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Detalles Bibliográficos
Autores principales:	Yoneyama, Yosuke, Lanzerstorfer, Peter, Niwa, Hideaki, Umehara, Takashi, Shibano, Takashi, Yokoyama, Shigeyuki, Chida, Kazuhiro, Weghuber, Julian, Hakuno, Fumihiko, Takahashi, Shin-Ichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903866/ https://www.ncbi.nlm.nih.gov/pubmed/29661273 http://dx.doi.org/10.7554/eLife.32893

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