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Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm

BACKGROUND & AIMS: Tissue hypoxia controls cell differentiation in the embryonic pancreas, and promotes tumor growth in pancreatic cancer. The cellular response to hypoxia is controlled by the hypoxia-inducible factor (HIF) proteins, including HIF2α. Previous studies of HIF action in the pancrea...

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Detalles Bibliográficos
Autores principales:	Schofield, Heather K., Tandon, Manuj, Park, Min-Jung, Halbrook, Christopher J., Ramakrishnan, Sadeesh K., Kim, Esther C., Shi, Jiaqi, Omary, M. Bishr, Shah, Yatrik M., Esni, Farzad, Pasca di Magliano, Marina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904051/ https://www.ncbi.nlm.nih.gov/pubmed/29693047 http://dx.doi.org/10.1016/j.jcmgh.2017.10.008

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