Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells

Neurofibromatosis type 1 (NF1) is caused by germline mutations in the NF1 gene and is characterized by café au lait spots and benign tumours known as neurofibromas. NF1 encodes the tumour suppressor protein neurofibromin, which negatively regulates the small GTPase Ras, with the constitutive activat...

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Detalles Bibliográficos
Autores principales: Harigai, Ritsuko, Sakai, Shigeki, Nobusue, Hiroyuki, Hirose, Chikako, Sampetrean, Oltea, Minami, Noriaki, Hata, Yukie, Kasama, Takashi, Hirose, Takanori, Takenouchi, Toshiki, Kosaki, Kenjiro, Kishi, Kazuo, Saya, Hideyuki, Arima, Yoshimi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904101/
https://www.ncbi.nlm.nih.gov/pubmed/29666462
http://dx.doi.org/10.1038/s41598-018-24484-y

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