Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

Chagas disease is caused by infection with the protozoan Trypanosoma cruzi (T. cruzi) and is an important cause of severe inflammatory heart disease. However, the mechanisms driving Chagas disease cardiomyopathy have not been completely elucidated. Here, we show that the canonical PI3Kγ pathway is u...

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Detalles Bibliográficos
Autores principales: Silva, Maria C., Davoli-Ferreira, Marcela, Medina, Tiago S., Sesti-Costa, Renata, Silva, Grace K., Lopes, Carla D., Cardozo, Lucas E., Gava, Fábio N., Lyroni, Konstantina, Dias, Fabrício C., Frade, Amanda F., Baron, Monique, Nakaya, Helder I., Figueiredo, Florêncio, Alves-Filho, José C., Cunha, Fernando Q., Tsatsanis, Christos, Chevillard, Christophe, Cunha-Neto, Edecio, Hirsch, Emilio, Silva, João S., Cunha, Thiago M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904108/
https://www.ncbi.nlm.nih.gov/pubmed/29666415
http://dx.doi.org/10.1038/s41467-018-03986-3

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