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Proscription supports robust perceptual integration by suppression in human visual cortex

Perception relies on integrating information within and between the senses, but how does the brain decide which pieces of information should be integrated and which kept separate? Here we demonstrate how proscription can be used to solve this problem: certain neurons respond best to unrealistic comb...

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Detalles Bibliográficos
Autores principales: Rideaux, Reuben, Welchman, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904115/
https://www.ncbi.nlm.nih.gov/pubmed/29666361
http://dx.doi.org/10.1038/s41467-018-03400-y
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author Rideaux, Reuben
Welchman, Andrew E.
author_facet Rideaux, Reuben
Welchman, Andrew E.
author_sort Rideaux, Reuben
collection PubMed
description Perception relies on integrating information within and between the senses, but how does the brain decide which pieces of information should be integrated and which kept separate? Here we demonstrate how proscription can be used to solve this problem: certain neurons respond best to unrealistic combinations of features to provide ‘what not’ information that drives suppression of unlikely perceptual interpretations. First, we present a model that captures both improved perception when signals are consistent (and thus should be integrated) and robust estimation when signals are conflicting. Second, we test for signatures of proscription in the human brain. We show that concentrations of inhibitory neurotransmitter GABA in a brain region intricately involved in integrating cues (V3B/KO) correlate with robust integration. Finally, we show that perturbing excitation/inhibition impairs integration. These results highlight the role of proscription in robust perception and demonstrate the functional purpose of ‘what not’ sensors in supporting sensory estimation.
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spelling pubmed-59041152018-04-20 Proscription supports robust perceptual integration by suppression in human visual cortex Rideaux, Reuben Welchman, Andrew E. Nat Commun Article Perception relies on integrating information within and between the senses, but how does the brain decide which pieces of information should be integrated and which kept separate? Here we demonstrate how proscription can be used to solve this problem: certain neurons respond best to unrealistic combinations of features to provide ‘what not’ information that drives suppression of unlikely perceptual interpretations. First, we present a model that captures both improved perception when signals are consistent (and thus should be integrated) and robust estimation when signals are conflicting. Second, we test for signatures of proscription in the human brain. We show that concentrations of inhibitory neurotransmitter GABA in a brain region intricately involved in integrating cues (V3B/KO) correlate with robust integration. Finally, we show that perturbing excitation/inhibition impairs integration. These results highlight the role of proscription in robust perception and demonstrate the functional purpose of ‘what not’ sensors in supporting sensory estimation. Nature Publishing Group UK 2018-04-17 /pmc/articles/PMC5904115/ /pubmed/29666361 http://dx.doi.org/10.1038/s41467-018-03400-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Rideaux, Reuben
Welchman, Andrew E.
Proscription supports robust perceptual integration by suppression in human visual cortex
title Proscription supports robust perceptual integration by suppression in human visual cortex
title_full Proscription supports robust perceptual integration by suppression in human visual cortex
title_fullStr Proscription supports robust perceptual integration by suppression in human visual cortex
title_full_unstemmed Proscription supports robust perceptual integration by suppression in human visual cortex
title_short Proscription supports robust perceptual integration by suppression in human visual cortex
title_sort proscription supports robust perceptual integration by suppression in human visual cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904115/
https://www.ncbi.nlm.nih.gov/pubmed/29666361
http://dx.doi.org/10.1038/s41467-018-03400-y
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