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Epidemiology and survival outcomes of mucinous adenocarcinomas: A SEER population-based study
To investigate the epidemiology, demographics and survival of mucinous adenocarcinomas (MACs), we identified 80,758 MAC patients in the Surveillance, Epidemiology and End Results (SEER) database. The reported incidence of MACs ebbed and flowed over time; however, a significant increase in reported a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904162/ https://www.ncbi.nlm.nih.gov/pubmed/29666453 http://dx.doi.org/10.1038/s41598-018-24540-7 |
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author | Xie, Guang-Dong Liu, Yi-Rong Jiang, Yi-Zhou Shao, Zhi-Ming |
author_facet | Xie, Guang-Dong Liu, Yi-Rong Jiang, Yi-Zhou Shao, Zhi-Ming |
author_sort | Xie, Guang-Dong |
collection | PubMed |
description | To investigate the epidemiology, demographics and survival of mucinous adenocarcinomas (MACs), we identified 80,758 MAC patients in the Surveillance, Epidemiology and End Results (SEER) database. The reported incidence of MACs ebbed and flowed over time; however, a significant increase in reported annual age-adjusted incidences of MACs in the appendix, lung and bronchus was observed from 1981 to 2014. The demographics and outcomes of MACs differed by anatomic sites. MACs of the stomach had the largest percentage of poorly differentiated or undifferentiated tumors (41.2%), while MACs of the appendix and pancreas were associated with more advanced tumor stage (P < 0.001). MACs of the pancreas, lung and bronchus and stomach showed worse survival than other sites, despite localized, regional or distant stage (P < 0.001). In univariate and multivariate analysis, site, tumor grade, tumor stage, regional nodes, sex, race, surgery and year of diagnosis were identified as independent prognostic factors of cancer-specific survival. In conclusion, the incidence of MACs of certain specific sites, such as the appendix, lung and bronchus, is rapidly increasing. We also revealed a series of prognostic factors of MACs, including tumor sites, tumor grade and tumor stage, which may improve the current understanding of the clinical and biological patterns of MACs. |
format | Online Article Text |
id | pubmed-5904162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59041622018-04-25 Epidemiology and survival outcomes of mucinous adenocarcinomas: A SEER population-based study Xie, Guang-Dong Liu, Yi-Rong Jiang, Yi-Zhou Shao, Zhi-Ming Sci Rep Article To investigate the epidemiology, demographics and survival of mucinous adenocarcinomas (MACs), we identified 80,758 MAC patients in the Surveillance, Epidemiology and End Results (SEER) database. The reported incidence of MACs ebbed and flowed over time; however, a significant increase in reported annual age-adjusted incidences of MACs in the appendix, lung and bronchus was observed from 1981 to 2014. The demographics and outcomes of MACs differed by anatomic sites. MACs of the stomach had the largest percentage of poorly differentiated or undifferentiated tumors (41.2%), while MACs of the appendix and pancreas were associated with more advanced tumor stage (P < 0.001). MACs of the pancreas, lung and bronchus and stomach showed worse survival than other sites, despite localized, regional or distant stage (P < 0.001). In univariate and multivariate analysis, site, tumor grade, tumor stage, regional nodes, sex, race, surgery and year of diagnosis were identified as independent prognostic factors of cancer-specific survival. In conclusion, the incidence of MACs of certain specific sites, such as the appendix, lung and bronchus, is rapidly increasing. We also revealed a series of prognostic factors of MACs, including tumor sites, tumor grade and tumor stage, which may improve the current understanding of the clinical and biological patterns of MACs. Nature Publishing Group UK 2018-04-17 /pmc/articles/PMC5904162/ /pubmed/29666453 http://dx.doi.org/10.1038/s41598-018-24540-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Xie, Guang-Dong Liu, Yi-Rong Jiang, Yi-Zhou Shao, Zhi-Ming Epidemiology and survival outcomes of mucinous adenocarcinomas: A SEER population-based study |
title | Epidemiology and survival outcomes of mucinous adenocarcinomas: A SEER population-based study |
title_full | Epidemiology and survival outcomes of mucinous adenocarcinomas: A SEER population-based study |
title_fullStr | Epidemiology and survival outcomes of mucinous adenocarcinomas: A SEER population-based study |
title_full_unstemmed | Epidemiology and survival outcomes of mucinous adenocarcinomas: A SEER population-based study |
title_short | Epidemiology and survival outcomes of mucinous adenocarcinomas: A SEER population-based study |
title_sort | epidemiology and survival outcomes of mucinous adenocarcinomas: a seer population-based study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904162/ https://www.ncbi.nlm.nih.gov/pubmed/29666453 http://dx.doi.org/10.1038/s41598-018-24540-7 |
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