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Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

Increased adiposity is a hallmark of obesity and overweight, which affect 2.2 billion people world-wide. Understanding the genetic and molecular mechanisms that underlie obesity-related phenotypes can help to improve treatment options and drug development. Here we perform promoter Capture Hi–C in hu...

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Detalles Bibliográficos
Autores principales:	Pan, David Z., Garske, Kristina M., Alvarez, Marcus, Bhagat, Yash V., Boocock, James, Nikkola, Elina, Miao, Zong, Raulerson, Chelsea K., Cantor, Rita M., Civelek, Mete, Glastonbury, Craig A., Small, Kerrin S., Boehnke, Michael, Lusis, Aldons J., Sinsheimer, Janet S., Mohlke, Karen L., Laakso, Markku, Pajukanta, Päivi, Ko, Arthur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904163/ https://www.ncbi.nlm.nih.gov/pubmed/29666371 http://dx.doi.org/10.1038/s41467-018-03554-9

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