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No Prophylactic Antibiotic Use for Young Children’s Intussusception with Low-risk Infection after Successful Air Enema Reduction

The Chinese government has issued the policy of promulgating the clinical use of antibacterial drugs since 2011. Prophylactic antibiotic use is a challenging problem among young children with intussusception after successful air enema reduction. There were limited data regarding the clinical value o...

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Autores principales: Zhang, Yuan, Zou, Wen, Ren, Lemeng, Zhang, Yinghui, Sun, Zhaohui, Liu, Huandi, Liu, Qian, Si, Chunfeng, Jia, Hongying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904166/
https://www.ncbi.nlm.nih.gov/pubmed/29666504
http://dx.doi.org/10.1038/s41598-018-24415-x
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author Zhang, Yuan
Zou, Wen
Ren, Lemeng
Zhang, Yinghui
Sun, Zhaohui
Liu, Huandi
Liu, Qian
Si, Chunfeng
Jia, Hongying
author_facet Zhang, Yuan
Zou, Wen
Ren, Lemeng
Zhang, Yinghui
Sun, Zhaohui
Liu, Huandi
Liu, Qian
Si, Chunfeng
Jia, Hongying
author_sort Zhang, Yuan
collection PubMed
description The Chinese government has issued the policy of promulgating the clinical use of antibacterial drugs since 2011. Prophylactic antibiotic use is a challenging problem among young children with intussusception after successful air enema reduction. There were limited data regarding the clinical value of prophylactic antibiotics for intussusception with low-risk infections. A retrospective non-randomized comparative study was conducted among 188 young children with intussusception after successful air enema reduction between January 1, 2011 and December 30, 2013. Among these children, 51 received prophylactic antibiotics and 137 did not receive antibiotics. Our results showed that there were no significant differences in age, gender, weight, admission period, reduction interval, axillary temperature, leukocytes, neutrophils, lymphocytes, monocytes, mesenteric lymph nodes and complications between groups (P > 0.05). The national policy had significantly improved clinical use of antibiotic for young children with low-risk intussusception (OR < 0.001, P < 0.001). Inpatients days were longer for children used antibiotics than those who did not (median, 27.0 hours vs 21.0 hours, P = 0.003). Prophylactic antibiotics appeared to be of little value after the successful air enema reduction of intussusception in young children with low-risk infection. Policy intervention is effective for antibiotic use in China.
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spelling pubmed-59041662018-04-25 No Prophylactic Antibiotic Use for Young Children’s Intussusception with Low-risk Infection after Successful Air Enema Reduction Zhang, Yuan Zou, Wen Ren, Lemeng Zhang, Yinghui Sun, Zhaohui Liu, Huandi Liu, Qian Si, Chunfeng Jia, Hongying Sci Rep Article The Chinese government has issued the policy of promulgating the clinical use of antibacterial drugs since 2011. Prophylactic antibiotic use is a challenging problem among young children with intussusception after successful air enema reduction. There were limited data regarding the clinical value of prophylactic antibiotics for intussusception with low-risk infections. A retrospective non-randomized comparative study was conducted among 188 young children with intussusception after successful air enema reduction between January 1, 2011 and December 30, 2013. Among these children, 51 received prophylactic antibiotics and 137 did not receive antibiotics. Our results showed that there were no significant differences in age, gender, weight, admission period, reduction interval, axillary temperature, leukocytes, neutrophils, lymphocytes, monocytes, mesenteric lymph nodes and complications between groups (P > 0.05). The national policy had significantly improved clinical use of antibiotic for young children with low-risk intussusception (OR < 0.001, P < 0.001). Inpatients days were longer for children used antibiotics than those who did not (median, 27.0 hours vs 21.0 hours, P = 0.003). Prophylactic antibiotics appeared to be of little value after the successful air enema reduction of intussusception in young children with low-risk infection. Policy intervention is effective for antibiotic use in China. Nature Publishing Group UK 2018-04-17 /pmc/articles/PMC5904166/ /pubmed/29666504 http://dx.doi.org/10.1038/s41598-018-24415-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhang, Yuan
Zou, Wen
Ren, Lemeng
Zhang, Yinghui
Sun, Zhaohui
Liu, Huandi
Liu, Qian
Si, Chunfeng
Jia, Hongying
No Prophylactic Antibiotic Use for Young Children’s Intussusception with Low-risk Infection after Successful Air Enema Reduction
title No Prophylactic Antibiotic Use for Young Children’s Intussusception with Low-risk Infection after Successful Air Enema Reduction
title_full No Prophylactic Antibiotic Use for Young Children’s Intussusception with Low-risk Infection after Successful Air Enema Reduction
title_fullStr No Prophylactic Antibiotic Use for Young Children’s Intussusception with Low-risk Infection after Successful Air Enema Reduction
title_full_unstemmed No Prophylactic Antibiotic Use for Young Children’s Intussusception with Low-risk Infection after Successful Air Enema Reduction
title_short No Prophylactic Antibiotic Use for Young Children’s Intussusception with Low-risk Infection after Successful Air Enema Reduction
title_sort no prophylactic antibiotic use for young children’s intussusception with low-risk infection after successful air enema reduction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904166/
https://www.ncbi.nlm.nih.gov/pubmed/29666504
http://dx.doi.org/10.1038/s41598-018-24415-x
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