In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility

T-cell immunity is controlled by T cell receptor (TCR) binding to peptide major histocompatibility complexes (pMHCs). The nature of the interaction between these two proteins has been the subject of many investigations because of its central role in immunity against pathogens, cancer, in autoimmunit...

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Detalles Bibliográficos
Autores principales: Holland, Christopher J., MacLachlan, Bruce J., Bianchi, Valentina, Hesketh, Sophie J., Morgan, Richard, Vickery, Owen, Bulek, Anna M., Fuller, Anna, Godkin, Andrew, Sewell, Andrew K., Rizkallah, Pierre J., Wells, Stephen, Cole, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904202/
https://www.ncbi.nlm.nih.gov/pubmed/29696015
http://dx.doi.org/10.3389/fimmu.2018.00674

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