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Lethal Zika Virus Disease Models in Young and Older Interferon α/β Receptor Knock Out Mice
The common small animal disease models for Zika virus (ZIKV) are mice lacking the interferon responses, but infection of interferon receptor α/β knock out (IFNAR(−/−)) mice is not uniformly lethal particularly in older animals. Here we sought to advance this model in regard to lethality for future c...
Autores principales: | Marzi, Andrea, Emanuel, Jackson, Callison, Julie, McNally, Kristin L., Arndt, Nicolette, Chadinha, Spencer, Martellaro, Cynthia, Rosenke, Rebecca, Scott, Dana P., Safronetz, David, Whitehead, Stephen S., Best, Sonja M., Feldmann, Heinz |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904210/ https://www.ncbi.nlm.nih.gov/pubmed/29696134 http://dx.doi.org/10.3389/fcimb.2018.00117 |
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