Cargando…
Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery
Amyloid-β (Aβ) is a peptide deposited in the brain parenchyma in Alzheimer’s disease and in cerebral blood vessels, causing cerebral amyloid angiopathy (CAA). Aβ pathology is transmissible experimentally in animals and through medical procedures in humans, such as contaminated growth hormone or dura...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904220/ https://www.ncbi.nlm.nih.gov/pubmed/29450646 http://dx.doi.org/10.1007/s00401-018-1822-2 |
_version_ | 1783315057332977664 |
---|---|
author | Jaunmuktane, Zane Quaegebeur, Annelies Taipa, Ricardo Viana-Baptista, Miguel Barbosa, Raquel Koriath, Carolin Sciot, Raf Mead, Simon Brandner, Sebastian |
author_facet | Jaunmuktane, Zane Quaegebeur, Annelies Taipa, Ricardo Viana-Baptista, Miguel Barbosa, Raquel Koriath, Carolin Sciot, Raf Mead, Simon Brandner, Sebastian |
author_sort | Jaunmuktane, Zane |
collection | PubMed |
description | Amyloid-β (Aβ) is a peptide deposited in the brain parenchyma in Alzheimer’s disease and in cerebral blood vessels, causing cerebral amyloid angiopathy (CAA). Aβ pathology is transmissible experimentally in animals and through medical procedures in humans, such as contaminated growth hormone or dura mater transplantation in the context of iatrogenic prion disease. Here, we present four patients who underwent neurosurgical procedures during childhood or teenage years and presented with intracerebral haemorrhage approximately three decades later, caused by severe CAA. None of these patients carried pathogenic mutations associated with early Aβ pathology development. In addition, we identified in the literature four patients with a history of neurosurgical intervention and subsequent development of CAA. These findings raise the possibility that Aβ pathology may be transmissible, as prion disease is, through neurosurgical procedures. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00401-018-1822-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5904220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-59042202018-04-24 Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery Jaunmuktane, Zane Quaegebeur, Annelies Taipa, Ricardo Viana-Baptista, Miguel Barbosa, Raquel Koriath, Carolin Sciot, Raf Mead, Simon Brandner, Sebastian Acta Neuropathol Original Paper Amyloid-β (Aβ) is a peptide deposited in the brain parenchyma in Alzheimer’s disease and in cerebral blood vessels, causing cerebral amyloid angiopathy (CAA). Aβ pathology is transmissible experimentally in animals and through medical procedures in humans, such as contaminated growth hormone or dura mater transplantation in the context of iatrogenic prion disease. Here, we present four patients who underwent neurosurgical procedures during childhood or teenage years and presented with intracerebral haemorrhage approximately three decades later, caused by severe CAA. None of these patients carried pathogenic mutations associated with early Aβ pathology development. In addition, we identified in the literature four patients with a history of neurosurgical intervention and subsequent development of CAA. These findings raise the possibility that Aβ pathology may be transmissible, as prion disease is, through neurosurgical procedures. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00401-018-1822-2) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2018-02-15 2018 /pmc/articles/PMC5904220/ /pubmed/29450646 http://dx.doi.org/10.1007/s00401-018-1822-2 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Paper Jaunmuktane, Zane Quaegebeur, Annelies Taipa, Ricardo Viana-Baptista, Miguel Barbosa, Raquel Koriath, Carolin Sciot, Raf Mead, Simon Brandner, Sebastian Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery |
title | Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery |
title_full | Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery |
title_fullStr | Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery |
title_full_unstemmed | Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery |
title_short | Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery |
title_sort | evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904220/ https://www.ncbi.nlm.nih.gov/pubmed/29450646 http://dx.doi.org/10.1007/s00401-018-1822-2 |
work_keys_str_mv | AT jaunmuktanezane evidenceofamyloidbcerebralamyloidangiopathytransmissionthroughneurosurgery AT quaegebeurannelies evidenceofamyloidbcerebralamyloidangiopathytransmissionthroughneurosurgery AT taiparicardo evidenceofamyloidbcerebralamyloidangiopathytransmissionthroughneurosurgery AT vianabaptistamiguel evidenceofamyloidbcerebralamyloidangiopathytransmissionthroughneurosurgery AT barbosaraquel evidenceofamyloidbcerebralamyloidangiopathytransmissionthroughneurosurgery AT koriathcarolin evidenceofamyloidbcerebralamyloidangiopathytransmissionthroughneurosurgery AT sciotraf evidenceofamyloidbcerebralamyloidangiopathytransmissionthroughneurosurgery AT meadsimon evidenceofamyloidbcerebralamyloidangiopathytransmissionthroughneurosurgery AT brandnersebastian evidenceofamyloidbcerebralamyloidangiopathytransmissionthroughneurosurgery |