An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity

Chimeric antigen receptors (CARs) are synthetic receptors that usually redirect T cells to surface antigens independent of human leukocyte antigen (HLA). Here, we investigated a T cell receptor-like CAR based on an antibody that recognizes HLA-A*0201 presenting a peptide epitope derived from the can...

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Detalles Bibliográficos
Autores principales: Maus, Marcela V, Plotkin, Jason, Jakka, Gopinadh, Stewart-Jones, Guillaume, Rivière, Isabelle, Merghoub, Taha, Wolchok, Jedd, Renner, Christoph, Sadelain, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904357/
https://www.ncbi.nlm.nih.gov/pubmed/29675462
http://dx.doi.org/10.1038/mto.2016.23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904357/
https://www.ncbi.nlm.nih.gov/pubmed/29675462
http://dx.doi.org/10.1038/mto.2016.23

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