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Diffusion-Weighted Imaging of Upper Abdominal Organs Acquired with Multiple B-Value Combinations: Value of Normalization Using Spleen as the Reference Organ

OBJECTIVE: To compare apparent diffusion coefficient (ADC) of the upper abdominal organs acquired with multiple b-value combinations and to investigate usefulness of normalization. MATERIALS AND METHODS: We retrospectively analyzed data, including 3T diffusion-weighted images, of 100 patients (56 me...

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Autores principales: Kim, Bo Ram, Song, Ji Soo, Choi, Eun Jung, Hwang, Seung Bae, Hwang, Hong Pil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Radiology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904465/
https://www.ncbi.nlm.nih.gov/pubmed/29713216
http://dx.doi.org/10.3348/kjr.2018.19.3.389
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author Kim, Bo Ram
Song, Ji Soo
Choi, Eun Jung
Hwang, Seung Bae
Hwang, Hong Pil
author_facet Kim, Bo Ram
Song, Ji Soo
Choi, Eun Jung
Hwang, Seung Bae
Hwang, Hong Pil
author_sort Kim, Bo Ram
collection PubMed
description OBJECTIVE: To compare apparent diffusion coefficient (ADC) of the upper abdominal organs acquired with multiple b-value combinations and to investigate usefulness of normalization. MATERIALS AND METHODS: We retrospectively analyzed data, including 3T diffusion-weighted images, of 100 patients (56 men, 44 women; mean age, 63.9) that underwent liver magnetic resonance imaging. An ADC map was derived with the following six b-value combinations: b(1) = 0, 50, 400, 800; b(2) = 0, 800; b(3) = 0, 50, 800; b(4) = 0, 400, 800; b(5) = 50, 800; and b(6) = 50, 400, 800 s/mm(2). ADC values of the right liver lobe, left liver lobe, spleen, pancreas, right kidney, and left kidney were measured. ADC values of the spleen were used for normalization. Intraclass correlation coefficients (ICCs), comparison of dependent ICCs, and repeated-measures analysis of variance were used for statistical analysis. RESULTS: Intraclass correlation coefficients of the original ADC revealed moderate to substantial agreement (0.5145–0.6509), while normalized ADCs revealed almost perfect agreement (0.8014–0.8569). ICC of normalized ADC for all anatomical regions revealed significantly less variability than that of the original ADC (p < 0.05). Coefficient of variance for normalized ADC was significantly lower than that for the original ADC (3.0.3.8% vs. 4.8.8.8%, p < 0.05). CONCLUSION: Normalization of the ADC values of the upper abdominal organs using the spleen as the reference organ significantly decreased variability in ADC measurement acquired with multiple b-value combinations.
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spelling pubmed-59044652018-05-01 Diffusion-Weighted Imaging of Upper Abdominal Organs Acquired with Multiple B-Value Combinations: Value of Normalization Using Spleen as the Reference Organ Kim, Bo Ram Song, Ji Soo Choi, Eun Jung Hwang, Seung Bae Hwang, Hong Pil Korean J Radiol Gastrointestinal Imaging OBJECTIVE: To compare apparent diffusion coefficient (ADC) of the upper abdominal organs acquired with multiple b-value combinations and to investigate usefulness of normalization. MATERIALS AND METHODS: We retrospectively analyzed data, including 3T diffusion-weighted images, of 100 patients (56 men, 44 women; mean age, 63.9) that underwent liver magnetic resonance imaging. An ADC map was derived with the following six b-value combinations: b(1) = 0, 50, 400, 800; b(2) = 0, 800; b(3) = 0, 50, 800; b(4) = 0, 400, 800; b(5) = 50, 800; and b(6) = 50, 400, 800 s/mm(2). ADC values of the right liver lobe, left liver lobe, spleen, pancreas, right kidney, and left kidney were measured. ADC values of the spleen were used for normalization. Intraclass correlation coefficients (ICCs), comparison of dependent ICCs, and repeated-measures analysis of variance were used for statistical analysis. RESULTS: Intraclass correlation coefficients of the original ADC revealed moderate to substantial agreement (0.5145–0.6509), while normalized ADCs revealed almost perfect agreement (0.8014–0.8569). ICC of normalized ADC for all anatomical regions revealed significantly less variability than that of the original ADC (p < 0.05). Coefficient of variance for normalized ADC was significantly lower than that for the original ADC (3.0.3.8% vs. 4.8.8.8%, p < 0.05). CONCLUSION: Normalization of the ADC values of the upper abdominal organs using the spleen as the reference organ significantly decreased variability in ADC measurement acquired with multiple b-value combinations. The Korean Society of Radiology 2018 2018-04-06 /pmc/articles/PMC5904465/ /pubmed/29713216 http://dx.doi.org/10.3348/kjr.2018.19.3.389 Text en Copyright © 2018 The Korean Society of Radiology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Gastrointestinal Imaging
Kim, Bo Ram
Song, Ji Soo
Choi, Eun Jung
Hwang, Seung Bae
Hwang, Hong Pil
Diffusion-Weighted Imaging of Upper Abdominal Organs Acquired with Multiple B-Value Combinations: Value of Normalization Using Spleen as the Reference Organ
title Diffusion-Weighted Imaging of Upper Abdominal Organs Acquired with Multiple B-Value Combinations: Value of Normalization Using Spleen as the Reference Organ
title_full Diffusion-Weighted Imaging of Upper Abdominal Organs Acquired with Multiple B-Value Combinations: Value of Normalization Using Spleen as the Reference Organ
title_fullStr Diffusion-Weighted Imaging of Upper Abdominal Organs Acquired with Multiple B-Value Combinations: Value of Normalization Using Spleen as the Reference Organ
title_full_unstemmed Diffusion-Weighted Imaging of Upper Abdominal Organs Acquired with Multiple B-Value Combinations: Value of Normalization Using Spleen as the Reference Organ
title_short Diffusion-Weighted Imaging of Upper Abdominal Organs Acquired with Multiple B-Value Combinations: Value of Normalization Using Spleen as the Reference Organ
title_sort diffusion-weighted imaging of upper abdominal organs acquired with multiple b-value combinations: value of normalization using spleen as the reference organ
topic Gastrointestinal Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904465/
https://www.ncbi.nlm.nih.gov/pubmed/29713216
http://dx.doi.org/10.3348/kjr.2018.19.3.389
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