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Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth

BACKGROUND: Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycle genes. Cardiac myocytes (CMs) accumulate heterochromatin during differentiati...

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Detalles Bibliográficos
Autores principales:	Oyama, Kyohei, El-Nachef, Danny, Fang, Chen, Kajimoto, Hidemi, Brown, Jeremy P., Singh, Prim B., MacLellan, W. Robb
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905015/ https://www.ncbi.nlm.nih.gov/pubmed/29665845 http://dx.doi.org/10.1186/s13072-018-0187-z

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