Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene

BACKGROUND: Improvement in genetic characterization of Colon Cancer (CC) patients is required to propose new potential targets, since surgical resection coupled to chemotherapy, presents several limits such as cancer recurrence and drug resistance. Targeted therapies have more efficacy and less toxi...

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Detalles Bibliográficos
Autores principales: Mendes Oliveira, Duarte, Grillone, Katia, Mignogna, Chiara, De Falco, Valentina, Laudanna, Carmelo, Biamonte, Flavia, Locane, Rosa, Corcione, Francesco, Fabozzi, Massimiliano, Sacco, Rosario, Viglietto, Giuseppe, Malanga, Donatella, Rizzuto, Antonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905113/
https://www.ncbi.nlm.nih.gov/pubmed/29665843
http://dx.doi.org/10.1186/s13046-018-0746-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905113/
https://www.ncbi.nlm.nih.gov/pubmed/29665843
http://dx.doi.org/10.1186/s13046-018-0746-y

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