Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities

BACKGROUND: There is considerable interest in defining the metabolic abnormalities of IDH mutant tumors to exploit for therapy. While most studies have attempted to discern function by using cell lines transduced with exogenous IDH mutant enzyme, in this study, we perform unbiased metabolomics to di...

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Detalles Bibliográficos
Autores principales: Garrett, Matthew, Sperry, Jantzen, Braas, Daniel, Yan, Weihong, Le, Thuc M., Mottahedeh, Jack, Ludwig, Kirsten, Eskin, Ascia, Qin, Yue, Levy, Rachelle, Breunig, Joshua J., Pajonk, Frank, Graeber, Thomas G., Radu, Caius G., Christofk, Heather, Prins, Robert M., Lai, Albert, Liau, Linda M., Coppola, Giovanni, Kornblum, Harley I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905129/
https://www.ncbi.nlm.nih.gov/pubmed/29692895
http://dx.doi.org/10.1186/s40170-018-0177-4

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