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The efficacy of intravenous aminocaproic acid in primary total hip and knee arthroplasty: a meta-analysis

BACKGROUND: We conducted a meta-analysis from randomized controlled trials (RCTs) and non-RCTs to assess the efficacy of aminocaproic acid in cases of primary total hip arthroplasty (THA) or total knee arthroplasty (TKA). METHODS: Potentially relevant academic articles were identified from the Cochr...

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Autores principales: Li, Yong-jiang, Xu, Bi-sheng, Bai, Sun-peng, Guo, Xiao-jun, Yan, Xiang-yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905142/
https://www.ncbi.nlm.nih.gov/pubmed/29665835
http://dx.doi.org/10.1186/s13018-018-0802-5
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author Li, Yong-jiang
Xu, Bi-sheng
Bai, Sun-peng
Guo, Xiao-jun
Yan, Xiang-yuan
author_facet Li, Yong-jiang
Xu, Bi-sheng
Bai, Sun-peng
Guo, Xiao-jun
Yan, Xiang-yuan
author_sort Li, Yong-jiang
collection PubMed
description BACKGROUND: We conducted a meta-analysis from randomized controlled trials (RCTs) and non-RCTs to assess the efficacy of aminocaproic acid in cases of primary total hip arthroplasty (THA) or total knee arthroplasty (TKA). METHODS: Potentially relevant academic articles were identified from the Cochrane Library, MEDLINE (1966–2017 October 31), PubMed (1966–2017 October 31), EMBASE (1980–2017 October 31), and ScienceDirect (1985–2017 October 31). Secondary sources were identified from the references of the included literature. The pooled data were analyzed using RevMan 5.1. RESULTS: Three RCTs and four non-RCTs met the inclusion criteria. There were significant differences in total blood loss (mean difference (MD) = − 495.80, 95% CI − 837.29 to − 154.32, P = 0.004), drainage volume (MD = − 249.43, 95% CI − 286.78 to − 212.08, P < 0.00001), postoperative hemoglobin level (MD = 0.90, 95% CI 0.78 to 1.02, P < 0.00001), hemoglobin reduction (MD = − 0.75, 95% CI − 0.93 to − 0.57, P < 0.00001), transfusion rates (risk difference (RD) = − 0.17, 95% CI − 0.25 to − 0.09, P < 0.0001), average transfusion units (MD = − 0.28, 95% CI − 0.48 to − 0.09, P = 0.004), and length of hospital stay (MD = − 0.33, 95% CI − 0.43 to − 0.24, P < 0.00001) between the two groups. No significant differences were found regarding deep vein thrombosis (DVT) (RD = − 0.00, 95% CI − 0.01 to 0.00, P = 0.36) between the two groups. CONCLUSIONS: The present meta-analysis indicated that the application of aminocaproic acid in THA or TKA decreases the total blood loss, drainage volume, transfusion rate, transfusion units per patient, and length of hospital stay and does not increase the risk of DVT.
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spelling pubmed-59051422018-04-24 The efficacy of intravenous aminocaproic acid in primary total hip and knee arthroplasty: a meta-analysis Li, Yong-jiang Xu, Bi-sheng Bai, Sun-peng Guo, Xiao-jun Yan, Xiang-yuan J Orthop Surg Res Research Article BACKGROUND: We conducted a meta-analysis from randomized controlled trials (RCTs) and non-RCTs to assess the efficacy of aminocaproic acid in cases of primary total hip arthroplasty (THA) or total knee arthroplasty (TKA). METHODS: Potentially relevant academic articles were identified from the Cochrane Library, MEDLINE (1966–2017 October 31), PubMed (1966–2017 October 31), EMBASE (1980–2017 October 31), and ScienceDirect (1985–2017 October 31). Secondary sources were identified from the references of the included literature. The pooled data were analyzed using RevMan 5.1. RESULTS: Three RCTs and four non-RCTs met the inclusion criteria. There were significant differences in total blood loss (mean difference (MD) = − 495.80, 95% CI − 837.29 to − 154.32, P = 0.004), drainage volume (MD = − 249.43, 95% CI − 286.78 to − 212.08, P < 0.00001), postoperative hemoglobin level (MD = 0.90, 95% CI 0.78 to 1.02, P < 0.00001), hemoglobin reduction (MD = − 0.75, 95% CI − 0.93 to − 0.57, P < 0.00001), transfusion rates (risk difference (RD) = − 0.17, 95% CI − 0.25 to − 0.09, P < 0.0001), average transfusion units (MD = − 0.28, 95% CI − 0.48 to − 0.09, P = 0.004), and length of hospital stay (MD = − 0.33, 95% CI − 0.43 to − 0.24, P < 0.00001) between the two groups. No significant differences were found regarding deep vein thrombosis (DVT) (RD = − 0.00, 95% CI − 0.01 to 0.00, P = 0.36) between the two groups. CONCLUSIONS: The present meta-analysis indicated that the application of aminocaproic acid in THA or TKA decreases the total blood loss, drainage volume, transfusion rate, transfusion units per patient, and length of hospital stay and does not increase the risk of DVT. BioMed Central 2018-04-17 /pmc/articles/PMC5905142/ /pubmed/29665835 http://dx.doi.org/10.1186/s13018-018-0802-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Li, Yong-jiang
Xu, Bi-sheng
Bai, Sun-peng
Guo, Xiao-jun
Yan, Xiang-yuan
The efficacy of intravenous aminocaproic acid in primary total hip and knee arthroplasty: a meta-analysis
title The efficacy of intravenous aminocaproic acid in primary total hip and knee arthroplasty: a meta-analysis
title_full The efficacy of intravenous aminocaproic acid in primary total hip and knee arthroplasty: a meta-analysis
title_fullStr The efficacy of intravenous aminocaproic acid in primary total hip and knee arthroplasty: a meta-analysis
title_full_unstemmed The efficacy of intravenous aminocaproic acid in primary total hip and knee arthroplasty: a meta-analysis
title_short The efficacy of intravenous aminocaproic acid in primary total hip and knee arthroplasty: a meta-analysis
title_sort efficacy of intravenous aminocaproic acid in primary total hip and knee arthroplasty: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905142/
https://www.ncbi.nlm.nih.gov/pubmed/29665835
http://dx.doi.org/10.1186/s13018-018-0802-5
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