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The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies
BACKGROUND: Isoflavones, a class of phytoestrogenic compounds, are abundant in soybeans. A number of epidemiological studies have investigated the association between dietary isoflavones intake and the risk of gastric cancer. However, the results are inconclusive. Therefore, the meta-analysis was co...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905165/ https://www.ncbi.nlm.nih.gov/pubmed/29665798 http://dx.doi.org/10.1186/s12889-018-5424-7 |
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author | You, Jie Sun, Yafei Bo, Yacong Zhu, Yiwei Duan, Dandan Cui, Han Lu, Quanjun |
author_facet | You, Jie Sun, Yafei Bo, Yacong Zhu, Yiwei Duan, Dandan Cui, Han Lu, Quanjun |
author_sort | You, Jie |
collection | PubMed |
description | BACKGROUND: Isoflavones, a class of phytoestrogenic compounds, are abundant in soybeans. A number of epidemiological studies have investigated the association between dietary isoflavones intake and the risk of gastric cancer. However, the results are inconclusive. Therefore, the meta-analysis was conducted to evaluate the effect of dietary isoflavones intake on the risk of gastric cancer. METHODS: Relevant studies from May 1992 to May 2017 were identified through searching PubMed and Web of Science. Additional articles were identified from the reference lists of relevant review articles. Pooled risk ratios (RRs) or odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed-effects model. Funnel plot and Egger’s test were used to evaluate publication bias. RESULTS: Seven articles reporting 12 studies were included in the current meta-analysis. We found no significant association between dietary isoflavones intake and gastric cancer risk with the highest versus the lowest categories of dietary isoflavones intake (OR = 0.97, 95% CI = 0.87–1.09, I(2) = 27.5%). Subgroup analyses generally yield similar results. CONCLUSIONS: Higher dietary isoflavones intake is not associated with a decline in the risk of gastric cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12889-018-5424-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5905165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-59051652018-04-24 The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies You, Jie Sun, Yafei Bo, Yacong Zhu, Yiwei Duan, Dandan Cui, Han Lu, Quanjun BMC Public Health Research Article BACKGROUND: Isoflavones, a class of phytoestrogenic compounds, are abundant in soybeans. A number of epidemiological studies have investigated the association between dietary isoflavones intake and the risk of gastric cancer. However, the results are inconclusive. Therefore, the meta-analysis was conducted to evaluate the effect of dietary isoflavones intake on the risk of gastric cancer. METHODS: Relevant studies from May 1992 to May 2017 were identified through searching PubMed and Web of Science. Additional articles were identified from the reference lists of relevant review articles. Pooled risk ratios (RRs) or odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed-effects model. Funnel plot and Egger’s test were used to evaluate publication bias. RESULTS: Seven articles reporting 12 studies were included in the current meta-analysis. We found no significant association between dietary isoflavones intake and gastric cancer risk with the highest versus the lowest categories of dietary isoflavones intake (OR = 0.97, 95% CI = 0.87–1.09, I(2) = 27.5%). Subgroup analyses generally yield similar results. CONCLUSIONS: Higher dietary isoflavones intake is not associated with a decline in the risk of gastric cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12889-018-5424-7) contains supplementary material, which is available to authorized users. BioMed Central 2018-04-17 /pmc/articles/PMC5905165/ /pubmed/29665798 http://dx.doi.org/10.1186/s12889-018-5424-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article You, Jie Sun, Yafei Bo, Yacong Zhu, Yiwei Duan, Dandan Cui, Han Lu, Quanjun The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies |
title | The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies |
title_full | The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies |
title_fullStr | The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies |
title_full_unstemmed | The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies |
title_short | The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies |
title_sort | association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905165/ https://www.ncbi.nlm.nih.gov/pubmed/29665798 http://dx.doi.org/10.1186/s12889-018-5424-7 |
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