Cargando…

The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion

In chromaffin cells, the kinetics of fusion pore expansion vary depending on which synaptotagmin isoform (Syt-1 or Syt-7) drives release. Our recent studies have shown that fusion pores of granules harboring Syt-1 expand more rapidly than those harboring Syt-7. Here we sought to define the structura...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bendahmane, Mounir, Bohannon, Kevin P., Bradberry, Mazdak M., Rao, Tejeshwar C., Schmidtke, Michael W., Abbineni, Prabhodh S., Chon, Nara L., Tran, Sherleen, Lin, Hai, Chapman, Edwin R., Knight, Jefferson D., Anantharam, Arun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905296/ https://www.ncbi.nlm.nih.gov/pubmed/29444959 http://dx.doi.org/10.1091/mbc.E17-11-0623

Ejemplares similares

Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules
por: Rao, Tejeshwar C., et al.
Publicado: (2017)

VAMP2 and synaptotagmin mobility in chromaffin granule membranes: implications for regulated exocytosis
por: Abbineni, Prabhodh S., et al.
Publicado: (2022)

Distinct fusion properties of synaptotagmin-1 and synaptotagmin-7 bearing dense core granules
por: Rao, Tejeshwar C., et al.
Publicado: (2014)

A Conserved Electrostatic Membrane-Binding Surface in Synaptotagmin-Like Proteins Revealed Using Molecular Phylogenetic Analysis and Homology Modeling
por: Chon, Nara L., et al.
Publicado: (2023)

Chromogranin A, the major lumenal protein in chromaffin granules, controls fusion pore expansion
por: Abbineni, Prabhodh S., et al.
Publicado: (2019)

Visualization of expanding fusion pores in secretory cells
por: Abbineni, Prabhodh S., et al.
Publicado: (2018)

The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis
por: MacDougall, Daniel D., et al.
Publicado: (2018)

Regulation of Exocytosis and Fusion Pores by Synaptotagmin-Effector Interactions
por: Zhang, Zhen, et al.
Publicado: (2010)

Synaptotagmin VII Restricts Fusion Pore Expansion during Lysosomal Exocytosis
por: Jaiswal, Jyoti K, et al.
Publicado: (2004)

Synaptotagmin-7 outperforms synaptotagmin-1 to promote the formation of large, stable fusion pores via robust membrane penetration
por: Courtney, Kevin C., et al.
Publicado: (2023)

Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin
por: Alnaas, Aml A., et al.
Publicado: (2020)

Application of High-Throughput Assays to Examine Phospho-Modulation of the Late Steps of Regulated Exocytosis
por: Abbineni, Prabhodh S., et al.
Publicado: (2017)

Conserved arginine residues in synaptotagmin 1 regulate fusion pore expansion through membrane contact
por: Nyenhuis, Sarah B., et al.
Publicado: (2021)

Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways
por: Ruhl, David A., et al.
Publicado: (2019)

Concurrent Binding of Complexin and Synaptotagmin to Liposome-Embedded SNARE Complexes
por: Chicka, Michael C., et al.
Publicado: (2009)

Mechanism and function of synaptotagmin-mediated membrane apposition
por: Hui, Enfu, et al.
Publicado: (2011)

Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening
por: Lai, Ying, et al.
Publicado: (2015)

Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion
por: Wang, Zhao, et al.
Publicado: (2011)

A new role for the dynamin GTPase in the regulation of fusion pore expansion
por: Anantharam, Arun, et al.
Publicado: (2011)

Synaptotagmin IV: A Multifunctional Regulator of Peptidergic Nerve Terminals
por: Zhang, Zhenjie, et al.
Publicado: (2009)

Synaptotagmin-7 links fusion-activated Ca(2+) entry and fusion pore dilation
por: Neuland, Kathrin, et al.
Publicado: (2014)

The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores
por: Wu, Zhenyong, et al.
Publicado: (2021)

N-glycoproteomics of brain synapses and synaptic vesicles
por: Bradberry, Mazdak M., et al.
Publicado: (2023)

Different states of synaptotagmin regulate evoked versus spontaneous release
por: Bai, Hua, et al.
Publicado: (2016)

Rat and Drosophila Synaptotagmin 4 Have Opposite Effects during SNARE-catalyzed Membrane Fusion
por: Wang, Zhao, et al.
Publicado: (2010)

Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9
por: Roper, Lindsey K., et al.
Publicado: (2015)

Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
por: Courtney, Nicholas A., et al.
Publicado: (2019)

Slow fusion pore expansion creates a unique reaction chamber for co-packaged cargo
por: Bohannon, Kevin P., et al.
Publicado: (2017)

Synaptotagmin-IV Modulates Synaptic Function and LTP by Regulating BDNF Release
por: Dean, Camin, et al.
Publicado: (2009)

Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells
por: Dong, Min, et al.
Publicado: (2003)

Analysis of the Synaptotagmin Family during Reconstituted Membrane Fusion: UNCOVERING A CLASS OF INHIBITORY ISOFORMS
por: Bhalla, Akhil, et al.
Publicado: (2008)

Glycosylation Is Dispensable for Sorting of Synaptotagmin 1 but Is Critical for Targeting of SV2 and Synaptophysin to Recycling Synaptic Vesicles
por: Kwon, Sung E., et al.
Publicado: (2012)

Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons
por: Vevea, Jason D, et al.
Publicado: (2020)

Identification of secreted proteins by comparison of protein abundance in conditioned media and cell lysates
por: Abbineni, Prabhodh S., et al.
Publicado: (2022)

Identification of LMAN1 and SURF4 dependent secretory cargoes
por: Tang, Vi T., et al.
Publicado: (2023)

Synaptotagmin 7 functions as a Ca(2+)-sensor for synaptic vesicle replenishment
por: Liu, Huisheng, et al.
Publicado: (2014)

Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1
por: Evans, Chantell S., et al.
Publicado: (2016)

Synaptotagmin 1 oligomerization via the juxtamembrane linker regulates spontaneous and evoked neurotransmitter release
por: Courtney, Kevin C., et al.
Publicado: (2021)

Synaptotagmin Function Illuminated
por: Lindau, Manfred
Publicado: (2003)

Ca(2+) and synaptotagmin VII–dependent delivery of lysosomal membrane to nascent phagosomes
por: Czibener, Cecilia, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_u3vt6snduu2n3hj0bge9hqvhof