Survival and glycemic control outcomes among patients with coexisting pancreatic cancer and diabetes mellitus

AIM: We aimed to determine the effect of diabetes mellitus (DM) on survival in pancreatic cancer and effects of pancreatic cancer on glycemic control in DM. MATERIALS & METHODS: Patients with pancreatic cancer from 2007 to 2015, with and without DM, were matched 1:1. We compared characteristics...

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Detalles Bibliográficos
Autores principales: Karlin, Nina J, Amin, Shailja B, Kosiorek, Heidi E, Buras, Matthew R, Verona, Patricia M, Cook, Curtiss B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905610/
https://www.ncbi.nlm.nih.gov/pubmed/29682326
http://dx.doi.org/10.4155/fsoa-2017-0144
Descripción
Sumario:AIM: We aimed to determine the effect of diabetes mellitus (DM) on survival in pancreatic cancer and effects of pancreatic cancer on glycemic control in DM. MATERIALS & METHODS: Patients with pancreatic cancer from 2007 to 2015, with and without DM, were matched 1:1. We compared characteristics between the groups and assessed 2-year survival with Kaplan–Meier analysis. RESULTS: In patients with DM, hemoglobin A(1c) decreased significantly over time (p = 0.01). In survival analysis, 2-year overall survival estimates were 15% (95% CI: 8–24%) for DM patients versus 26% (95% CI: 17–36%) for non-DM patients (p = 0.55). The hazard ratio for matched pairs was 1.15 (95% CI: 0.75–1.77; p = 0.51). CONCLUSION: DM did not decrease survival in pancreatic cancer. Pancreatic cancer did not affect glycemic control.

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