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The Evolutionary History of Nebraska Deer Mice: Local Adaptation in the Face of Strong Gene Flow

The interplay of gene flow, genetic drift, and local selective pressure is a dynamic process that has been well studied from a theoretical perspective over the last century. Wright and Haldane laid the foundation for expectations under an island-continent model, demonstrating that an island-specific...

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Autores principales: Pfeifer, Susanne P, Laurent, Stefan, Sousa, Vitor C, Linnen, Catherine R, Foll, Matthieu, Excoffier, Laurent, Hoekstra, Hopi E, Jensen, Jeffrey D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905656/
https://www.ncbi.nlm.nih.gov/pubmed/29346646
http://dx.doi.org/10.1093/molbev/msy004
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author Pfeifer, Susanne P
Laurent, Stefan
Sousa, Vitor C
Linnen, Catherine R
Foll, Matthieu
Excoffier, Laurent
Hoekstra, Hopi E
Jensen, Jeffrey D
author_facet Pfeifer, Susanne P
Laurent, Stefan
Sousa, Vitor C
Linnen, Catherine R
Foll, Matthieu
Excoffier, Laurent
Hoekstra, Hopi E
Jensen, Jeffrey D
author_sort Pfeifer, Susanne P
collection PubMed
description The interplay of gene flow, genetic drift, and local selective pressure is a dynamic process that has been well studied from a theoretical perspective over the last century. Wright and Haldane laid the foundation for expectations under an island-continent model, demonstrating that an island-specific beneficial allele may be maintained locally if the selection coefficient is larger than the rate of migration of the ancestral allele from the continent. Subsequent extensions of this model have provided considerably more insight. Yet, connecting theoretical results with empirical data has proven challenging, owing to a lack of information on the relationship between genotype, phenotype, and fitness. Here, we examine the demographic and selective history of deer mice in and around the Nebraska Sand Hills, a system in which variation at the Agouti locus affects cryptic coloration that in turn affects the survival of mice in their local habitat. We first genotyped 250 individuals from 11 sites along a transect spanning the Sand Hills at 660,000 single nucleotide polymorphisms across the genome. Using these genomic data, we found that deer mice first colonized the Sand Hills following the last glacial period. Subsequent high rates of gene flow have served to homogenize the majority of the genome between populations on and off the Sand Hills, with the exception of the Agouti pigmentation locus. Furthermore, mutations at this locus are strongly associated with the pigment traits that are strongly correlated with local soil coloration and thus responsible for cryptic coloration.
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spelling pubmed-59056562018-04-23 The Evolutionary History of Nebraska Deer Mice: Local Adaptation in the Face of Strong Gene Flow Pfeifer, Susanne P Laurent, Stefan Sousa, Vitor C Linnen, Catherine R Foll, Matthieu Excoffier, Laurent Hoekstra, Hopi E Jensen, Jeffrey D Mol Biol Evol Fast Track The interplay of gene flow, genetic drift, and local selective pressure is a dynamic process that has been well studied from a theoretical perspective over the last century. Wright and Haldane laid the foundation for expectations under an island-continent model, demonstrating that an island-specific beneficial allele may be maintained locally if the selection coefficient is larger than the rate of migration of the ancestral allele from the continent. Subsequent extensions of this model have provided considerably more insight. Yet, connecting theoretical results with empirical data has proven challenging, owing to a lack of information on the relationship between genotype, phenotype, and fitness. Here, we examine the demographic and selective history of deer mice in and around the Nebraska Sand Hills, a system in which variation at the Agouti locus affects cryptic coloration that in turn affects the survival of mice in their local habitat. We first genotyped 250 individuals from 11 sites along a transect spanning the Sand Hills at 660,000 single nucleotide polymorphisms across the genome. Using these genomic data, we found that deer mice first colonized the Sand Hills following the last glacial period. Subsequent high rates of gene flow have served to homogenize the majority of the genome between populations on and off the Sand Hills, with the exception of the Agouti pigmentation locus. Furthermore, mutations at this locus are strongly associated with the pigment traits that are strongly correlated with local soil coloration and thus responsible for cryptic coloration. Oxford University Press 2018-04 2018-01-15 /pmc/articles/PMC5905656/ /pubmed/29346646 http://dx.doi.org/10.1093/molbev/msy004 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Fast Track
Pfeifer, Susanne P
Laurent, Stefan
Sousa, Vitor C
Linnen, Catherine R
Foll, Matthieu
Excoffier, Laurent
Hoekstra, Hopi E
Jensen, Jeffrey D
The Evolutionary History of Nebraska Deer Mice: Local Adaptation in the Face of Strong Gene Flow
title The Evolutionary History of Nebraska Deer Mice: Local Adaptation in the Face of Strong Gene Flow
title_full The Evolutionary History of Nebraska Deer Mice: Local Adaptation in the Face of Strong Gene Flow
title_fullStr The Evolutionary History of Nebraska Deer Mice: Local Adaptation in the Face of Strong Gene Flow
title_full_unstemmed The Evolutionary History of Nebraska Deer Mice: Local Adaptation in the Face of Strong Gene Flow
title_short The Evolutionary History of Nebraska Deer Mice: Local Adaptation in the Face of Strong Gene Flow
title_sort evolutionary history of nebraska deer mice: local adaptation in the face of strong gene flow
topic Fast Track
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905656/
https://www.ncbi.nlm.nih.gov/pubmed/29346646
http://dx.doi.org/10.1093/molbev/msy004
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