Cargando…

Multispectral, non-contact diffuse optical tomography of healthy human finger joints

Rheumatoid arthritis (RA) is an inflammatory joint disease often affecting the hands, which if untreated causes disability. Diffuse optical tomography (DOT) provides information about the underlying functional properties of biological tissue. To detect pathophysiological changes in inflamed RA joint...

Descripción completa

Detalles Bibliográficos
Autores principales: Lighter, Daniel, Hughes, James, Styles, Iain, Filer, Andrew, Dehghani, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905898/
https://www.ncbi.nlm.nih.gov/pubmed/29675294
http://dx.doi.org/10.1364/BOE.9.001445
Descripción
Sumario:Rheumatoid arthritis (RA) is an inflammatory joint disease often affecting the hands, which if untreated causes disability. Diffuse optical tomography (DOT) provides information about the underlying functional properties of biological tissue. To detect pathophysiological changes in inflamed RA joints, a good understanding of the baseline values for healthy subjects is first required. Finger joints from healthy subjects were imaged using a non-contact, multispectral, continuous wave DOT system, recovering physiological parameters of oxygen saturation, total haemoglobin, water concentration and scatter amplitude. Reconstructed values across the cohort demonstrated good consistency between finger joints from the same participant, with greater variation seen between subjects.