Cargando…
The Caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell
C. elegans cell divisions that produce an apoptotic daughter cell exhibit Daughter Cell Size Asymmetry (DCSA), producing a larger surviving daughter cell and a smaller daughter cell fated to die. Genetic screens for mutants with defects in apoptosis identified several genes that are also required fo...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905977/ https://www.ncbi.nlm.nih.gov/pubmed/29668718 http://dx.doi.org/10.1371/journal.pone.0195855 |
_version_ | 1783315334787235840 |
---|---|
author | Teuliere, Jerome Kovacevic, Ismar Bao, Zhirong Garriga, Gian |
author_facet | Teuliere, Jerome Kovacevic, Ismar Bao, Zhirong Garriga, Gian |
author_sort | Teuliere, Jerome |
collection | PubMed |
description | C. elegans cell divisions that produce an apoptotic daughter cell exhibit Daughter Cell Size Asymmetry (DCSA), producing a larger surviving daughter cell and a smaller daughter cell fated to die. Genetic screens for mutants with defects in apoptosis identified several genes that are also required for the ability of these divisions to produce daughter cells that differ in size. One of these genes, ham-1, encodes a putative transcription factor that regulates a subset of the asymmetric cell divisions that produce an apoptotic daughter cell. In a survey of C. elegans divisions, we found that ham-1 mutations affect primarily anterior/posterior divisions that produce a small anterior daughter cell. The affected divisions include those that generate an apoptotic cell as well as those that generate two surviving cells. Our findings suggest that HAM-1 primarily promotes DCSA in a certain class of asymmetric divisions. |
format | Online Article Text |
id | pubmed-5905977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-59059772018-05-06 The Caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell Teuliere, Jerome Kovacevic, Ismar Bao, Zhirong Garriga, Gian PLoS One Research Article C. elegans cell divisions that produce an apoptotic daughter cell exhibit Daughter Cell Size Asymmetry (DCSA), producing a larger surviving daughter cell and a smaller daughter cell fated to die. Genetic screens for mutants with defects in apoptosis identified several genes that are also required for the ability of these divisions to produce daughter cells that differ in size. One of these genes, ham-1, encodes a putative transcription factor that regulates a subset of the asymmetric cell divisions that produce an apoptotic daughter cell. In a survey of C. elegans divisions, we found that ham-1 mutations affect primarily anterior/posterior divisions that produce a small anterior daughter cell. The affected divisions include those that generate an apoptotic cell as well as those that generate two surviving cells. Our findings suggest that HAM-1 primarily promotes DCSA in a certain class of asymmetric divisions. Public Library of Science 2018-04-18 /pmc/articles/PMC5905977/ /pubmed/29668718 http://dx.doi.org/10.1371/journal.pone.0195855 Text en © 2018 Teuliere et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Teuliere, Jerome Kovacevic, Ismar Bao, Zhirong Garriga, Gian The Caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell |
title | The Caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell |
title_full | The Caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell |
title_fullStr | The Caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell |
title_full_unstemmed | The Caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell |
title_short | The Caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell |
title_sort | caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905977/ https://www.ncbi.nlm.nih.gov/pubmed/29668718 http://dx.doi.org/10.1371/journal.pone.0195855 |
work_keys_str_mv | AT teulierejerome thecaenorhabditiselegansgeneham1regulatesdaughtercellsizeasymmetryprimarilyindivisionsthatproduceasmallanteriordaughtercell AT kovacevicismar thecaenorhabditiselegansgeneham1regulatesdaughtercellsizeasymmetryprimarilyindivisionsthatproduceasmallanteriordaughtercell AT baozhirong thecaenorhabditiselegansgeneham1regulatesdaughtercellsizeasymmetryprimarilyindivisionsthatproduceasmallanteriordaughtercell AT garrigagian thecaenorhabditiselegansgeneham1regulatesdaughtercellsizeasymmetryprimarilyindivisionsthatproduceasmallanteriordaughtercell AT teulierejerome caenorhabditiselegansgeneham1regulatesdaughtercellsizeasymmetryprimarilyindivisionsthatproduceasmallanteriordaughtercell AT kovacevicismar caenorhabditiselegansgeneham1regulatesdaughtercellsizeasymmetryprimarilyindivisionsthatproduceasmallanteriordaughtercell AT baozhirong caenorhabditiselegansgeneham1regulatesdaughtercellsizeasymmetryprimarilyindivisionsthatproduceasmallanteriordaughtercell AT garrigagian caenorhabditiselegansgeneham1regulatesdaughtercellsizeasymmetryprimarilyindivisionsthatproduceasmallanteriordaughtercell |