Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats

Purpose  The purpose of this study is to verify migration of mesenchymal stem cells of bursal tissue into the healing site after rotator cuff repair in rats. Methods  Fischer rats and green fluorescent protein (GFP)-transgenic rats were used. Bursal tissue from GFP rats was isolated and transplanted...

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Autores principales: Safi, Elem, Ficklscherer, Andreas, Bondarava, Maryna, Betz, Oliver, Zhang, Anja, Jansson, Volkmar, Müller, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906115/
https://www.ncbi.nlm.nih.gov/pubmed/29675500
http://dx.doi.org/10.1055/s-0038-1636948
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author Safi, Elem
Ficklscherer, Andreas
Bondarava, Maryna
Betz, Oliver
Zhang, Anja
Jansson, Volkmar
Müller, Peter E.
author_facet Safi, Elem
Ficklscherer, Andreas
Bondarava, Maryna
Betz, Oliver
Zhang, Anja
Jansson, Volkmar
Müller, Peter E.
author_sort Safi, Elem
collection PubMed
description Purpose  The purpose of this study is to verify migration of mesenchymal stem cells of bursal tissue into the healing site after rotator cuff repair in rats. Methods  Fischer rats and green fluorescent protein (GFP)-transgenic rats were used. Bursal tissue from GFP rats was isolated and transplanted into tendon repair sites in Fischer rats. We examined the histology of the rotator cuff and the proportion of GFP-positive cells in the repaired rotator cuff 1, 3, and 6 weeks after surgery. Results  Cell migration was observed during the third and sixth week after surgery. We also found mesenchymal stem cells and formed bursal cluster patterns in the repaired rotator cuff tendons. Conclusion  Mesenchymal stem cells migrated from bursal tissue and infiltrated the repaired rotator cuff tendons. Clinical Relevance  Mesenchymal stem cells from bursal tissue can contribute to the healing progress of the repaired rotator cuff.
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spelling pubmed-59061152018-04-19 Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats Safi, Elem Ficklscherer, Andreas Bondarava, Maryna Betz, Oliver Zhang, Anja Jansson, Volkmar Müller, Peter E. Joints Purpose  The purpose of this study is to verify migration of mesenchymal stem cells of bursal tissue into the healing site after rotator cuff repair in rats. Methods  Fischer rats and green fluorescent protein (GFP)-transgenic rats were used. Bursal tissue from GFP rats was isolated and transplanted into tendon repair sites in Fischer rats. We examined the histology of the rotator cuff and the proportion of GFP-positive cells in the repaired rotator cuff 1, 3, and 6 weeks after surgery. Results  Cell migration was observed during the third and sixth week after surgery. We also found mesenchymal stem cells and formed bursal cluster patterns in the repaired rotator cuff tendons. Conclusion  Mesenchymal stem cells migrated from bursal tissue and infiltrated the repaired rotator cuff tendons. Clinical Relevance  Mesenchymal stem cells from bursal tissue can contribute to the healing progress of the repaired rotator cuff. Georg Thieme Verlag KG 2018-03-13 /pmc/articles/PMC5906115/ /pubmed/29675500 http://dx.doi.org/10.1055/s-0038-1636948 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Safi, Elem
Ficklscherer, Andreas
Bondarava, Maryna
Betz, Oliver
Zhang, Anja
Jansson, Volkmar
Müller, Peter E.
Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats
title Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats
title_full Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats
title_fullStr Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats
title_full_unstemmed Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats
title_short Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats
title_sort migration of mesenchymal stem cells of bursal tissue after rotator cuff repair in rats
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906115/
https://www.ncbi.nlm.nih.gov/pubmed/29675500
http://dx.doi.org/10.1055/s-0038-1636948
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