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Racial Differences in Neonatal Hypoglycemia among Very Early Preterm Births

OBJECTIVE: To determine whether the prevalence of neonatal hypoglycemia differs by race/ethnicity. STUDY DESIGN: A retrospective cohort study using prospectively collected data from 515 neonates born very preterm (<32 weeks) to normoglycemic women and admitted to the neonatal intensive care unit...

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Detalles Bibliográficos
Autores principales: James-Todd, Tamarra, March, Melissa I., Seiglie, Jacqueline, Gupta, Munish, Brown, Florence M., Majzoub, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906150/
https://www.ncbi.nlm.nih.gov/pubmed/29209031
http://dx.doi.org/10.1038/s41372-017-0003-9
Descripción
Sumario:OBJECTIVE: To determine whether the prevalence of neonatal hypoglycemia differs by race/ethnicity. STUDY DESIGN: A retrospective cohort study using prospectively collected data from 515 neonates born very preterm (<32 weeks) to normoglycemic women and admitted to the neonatal intensive care unit (NICU) at a major tertiary hospital in Boston, MA between 2008 and 2012. RESULTS: A total of 61%, 12%, 7%, 7%, and 13% were White, Black, Hispanic, Asian, and Other, respectively. Among the 66% spontaneous preterm births, 63% of the black neonates experienced hypoglycemia (blood glucose level<40 mg/dL), while only 22–30% of the other racial/ethnic neonates did so (Black v. White RR 2.15; 95% CI: 1.54–3.00). After adjusting for maternal education, maternal age, multiple gestations, delivery type, gestational age, birth weight and neonates’ sex, this association remained significant (adjusted Black v. White RR: 1.61, 95% CI: 1.13–2.29). An increased risk of infant hypoglycemia was not seen in infants of other racial/ethnic groups, nor in any racial/ethnic group with a medically-indicated preterm birth. CONCLUSIONS: Black neonates delivered for spontaneous (but not medical) indications at <32 weeks had a higher risk of hypoglycemia, which could provide critical information about mechanisms of preterm birth and adverse postnatal outcomes in this high-risk group.