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TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
Sexual dimorphism exists in energy balance, but the underlying mechanisms remain unclear. Here we show that the female mice have more pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus than males, and female POMC neurons display higher neural activities, compared to male coun...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906443/ https://www.ncbi.nlm.nih.gov/pubmed/29670083 http://dx.doi.org/10.1038/s41467-018-03796-7 |
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author | Wang, Chunmei He, Yanlin Xu, Pingwen Yang, Yongjie Saito, Kenji Xia, Yan Yan, Xiaofeng Hinton Jr, Antentor Yan, Chunling Ding, Hongfang Yu, Likai Shu, Gang Gupta, Rajat Wu, Qi Tong, Qingchun Lagor, William R. Flores, Elsa R. Xu, Yong |
author_facet | Wang, Chunmei He, Yanlin Xu, Pingwen Yang, Yongjie Saito, Kenji Xia, Yan Yan, Xiaofeng Hinton Jr, Antentor Yan, Chunling Ding, Hongfang Yu, Likai Shu, Gang Gupta, Rajat Wu, Qi Tong, Qingchun Lagor, William R. Flores, Elsa R. Xu, Yong |
author_sort | Wang, Chunmei |
collection | PubMed |
description | Sexual dimorphism exists in energy balance, but the underlying mechanisms remain unclear. Here we show that the female mice have more pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus than males, and female POMC neurons display higher neural activities, compared to male counterparts. Strikingly, deletion of the transcription factor, TAp63, in POMC neurons confers “male-like” diet-induced obesity (DIO) in female mice associated with decreased POMC neural activities; but the same deletion does not affect male mice. Our results indicate that TAp63 in female POMC neurons contributes to the enhanced POMC neuron functions and resistance to obesity in females. Thus, TAp63 in POMC neurons is one key molecular driver for the sexual dimorphism in energy homeostasis. |
format | Online Article Text |
id | pubmed-5906443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59064432018-04-20 TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis Wang, Chunmei He, Yanlin Xu, Pingwen Yang, Yongjie Saito, Kenji Xia, Yan Yan, Xiaofeng Hinton Jr, Antentor Yan, Chunling Ding, Hongfang Yu, Likai Shu, Gang Gupta, Rajat Wu, Qi Tong, Qingchun Lagor, William R. Flores, Elsa R. Xu, Yong Nat Commun Article Sexual dimorphism exists in energy balance, but the underlying mechanisms remain unclear. Here we show that the female mice have more pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus than males, and female POMC neurons display higher neural activities, compared to male counterparts. Strikingly, deletion of the transcription factor, TAp63, in POMC neurons confers “male-like” diet-induced obesity (DIO) in female mice associated with decreased POMC neural activities; but the same deletion does not affect male mice. Our results indicate that TAp63 in female POMC neurons contributes to the enhanced POMC neuron functions and resistance to obesity in females. Thus, TAp63 in POMC neurons is one key molecular driver for the sexual dimorphism in energy homeostasis. Nature Publishing Group UK 2018-04-18 /pmc/articles/PMC5906443/ /pubmed/29670083 http://dx.doi.org/10.1038/s41467-018-03796-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wang, Chunmei He, Yanlin Xu, Pingwen Yang, Yongjie Saito, Kenji Xia, Yan Yan, Xiaofeng Hinton Jr, Antentor Yan, Chunling Ding, Hongfang Yu, Likai Shu, Gang Gupta, Rajat Wu, Qi Tong, Qingchun Lagor, William R. Flores, Elsa R. Xu, Yong TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis |
title | TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis |
title_full | TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis |
title_fullStr | TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis |
title_full_unstemmed | TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis |
title_short | TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis |
title_sort | tap63 contributes to sexual dimorphism in pomc neuron functions and energy homeostasis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906443/ https://www.ncbi.nlm.nih.gov/pubmed/29670083 http://dx.doi.org/10.1038/s41467-018-03796-7 |
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