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TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

Sexual dimorphism exists in energy balance, but the underlying mechanisms remain unclear. Here we show that the female mice have more pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus than males, and female POMC neurons display higher neural activities, compared to male coun...

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Autores principales: Wang, Chunmei, He, Yanlin, Xu, Pingwen, Yang, Yongjie, Saito, Kenji, Xia, Yan, Yan, Xiaofeng, Hinton Jr, Antentor, Yan, Chunling, Ding, Hongfang, Yu, Likai, Shu, Gang, Gupta, Rajat, Wu, Qi, Tong, Qingchun, Lagor, William R., Flores, Elsa R., Xu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906443/
https://www.ncbi.nlm.nih.gov/pubmed/29670083
http://dx.doi.org/10.1038/s41467-018-03796-7
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author Wang, Chunmei
He, Yanlin
Xu, Pingwen
Yang, Yongjie
Saito, Kenji
Xia, Yan
Yan, Xiaofeng
Hinton Jr, Antentor
Yan, Chunling
Ding, Hongfang
Yu, Likai
Shu, Gang
Gupta, Rajat
Wu, Qi
Tong, Qingchun
Lagor, William R.
Flores, Elsa R.
Xu, Yong
author_facet Wang, Chunmei
He, Yanlin
Xu, Pingwen
Yang, Yongjie
Saito, Kenji
Xia, Yan
Yan, Xiaofeng
Hinton Jr, Antentor
Yan, Chunling
Ding, Hongfang
Yu, Likai
Shu, Gang
Gupta, Rajat
Wu, Qi
Tong, Qingchun
Lagor, William R.
Flores, Elsa R.
Xu, Yong
author_sort Wang, Chunmei
collection PubMed
description Sexual dimorphism exists in energy balance, but the underlying mechanisms remain unclear. Here we show that the female mice have more pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus than males, and female POMC neurons display higher neural activities, compared to male counterparts. Strikingly, deletion of the transcription factor, TAp63, in POMC neurons confers “male-like” diet-induced obesity (DIO) in female mice associated with decreased POMC neural activities; but the same deletion does not affect male mice. Our results indicate that TAp63 in female POMC neurons contributes to the enhanced POMC neuron functions and resistance to obesity in females. Thus, TAp63 in POMC neurons is one key molecular driver for the sexual dimorphism in energy homeostasis.
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spelling pubmed-59064432018-04-20 TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis Wang, Chunmei He, Yanlin Xu, Pingwen Yang, Yongjie Saito, Kenji Xia, Yan Yan, Xiaofeng Hinton Jr, Antentor Yan, Chunling Ding, Hongfang Yu, Likai Shu, Gang Gupta, Rajat Wu, Qi Tong, Qingchun Lagor, William R. Flores, Elsa R. Xu, Yong Nat Commun Article Sexual dimorphism exists in energy balance, but the underlying mechanisms remain unclear. Here we show that the female mice have more pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus than males, and female POMC neurons display higher neural activities, compared to male counterparts. Strikingly, deletion of the transcription factor, TAp63, in POMC neurons confers “male-like” diet-induced obesity (DIO) in female mice associated with decreased POMC neural activities; but the same deletion does not affect male mice. Our results indicate that TAp63 in female POMC neurons contributes to the enhanced POMC neuron functions and resistance to obesity in females. Thus, TAp63 in POMC neurons is one key molecular driver for the sexual dimorphism in energy homeostasis. Nature Publishing Group UK 2018-04-18 /pmc/articles/PMC5906443/ /pubmed/29670083 http://dx.doi.org/10.1038/s41467-018-03796-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wang, Chunmei
He, Yanlin
Xu, Pingwen
Yang, Yongjie
Saito, Kenji
Xia, Yan
Yan, Xiaofeng
Hinton Jr, Antentor
Yan, Chunling
Ding, Hongfang
Yu, Likai
Shu, Gang
Gupta, Rajat
Wu, Qi
Tong, Qingchun
Lagor, William R.
Flores, Elsa R.
Xu, Yong
TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
title TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
title_full TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
title_fullStr TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
title_full_unstemmed TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
title_short TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
title_sort tap63 contributes to sexual dimorphism in pomc neuron functions and energy homeostasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906443/
https://www.ncbi.nlm.nih.gov/pubmed/29670083
http://dx.doi.org/10.1038/s41467-018-03796-7
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