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IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population

Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole IL13 gene (i.e., rs1881457, rs2069744 and rs20541) and a two-st...

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Autores principales: Zha, Ling-Feng, Nie, Shao-Fang, Chen, Qian-Wen, Liao, Yu-Hua, Zhang, Hong-Song, Dong, Jiang-Tao, Xie, Tian, Wang, Fan, Tang, Ting-Ting, Xia, Ni, Xu, Cheng-Qi, Zhou, Ying-Chao, Zeng, Zhi-Peng, Jiao, Jiao, Wang, Peng-Yun, Wang, Qing K., Tu, Xin, Cheng, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906444/
https://www.ncbi.nlm.nih.gov/pubmed/29670225
http://dx.doi.org/10.1038/s41598-018-24592-9
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author Zha, Ling-Feng
Nie, Shao-Fang
Chen, Qian-Wen
Liao, Yu-Hua
Zhang, Hong-Song
Dong, Jiang-Tao
Xie, Tian
Wang, Fan
Tang, Ting-Ting
Xia, Ni
Xu, Cheng-Qi
Zhou, Ying-Chao
Zeng, Zhi-Peng
Jiao, Jiao
Wang, Peng-Yun
Wang, Qing K.
Tu, Xin
Cheng, Xiang
author_facet Zha, Ling-Feng
Nie, Shao-Fang
Chen, Qian-Wen
Liao, Yu-Hua
Zhang, Hong-Song
Dong, Jiang-Tao
Xie, Tian
Wang, Fan
Tang, Ting-Ting
Xia, Ni
Xu, Cheng-Qi
Zhou, Ying-Chao
Zeng, Zhi-Peng
Jiao, Jiao
Wang, Peng-Yun
Wang, Qing K.
Tu, Xin
Cheng, Xiang
author_sort Zha, Ling-Feng
collection PubMed
description Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole IL13 gene (i.e., rs1881457, rs2069744 and rs20541) and a two-stage cohort containing 1863 CAD cases and 1841 controls. Traditional risk factors for CAD, such as age, BMI, and other factors, were used as covariates in logistic regression analysis. In the total population, we found that two haplotypes of IL13 (ATG and ATA, ordered rs1881457(C)-rs2069744(T)-rs20541(A)) significantly contributed to the risk of CAD with adjusted p values less than 0.05 (p(adj) = 0.019 and p(adj) = 0.042, respectively). In subgroup population analyses, the variant rs1881457(C) was found to significantly contribute to a nearly two fold increase in the risk of CAD in men (p(adj) = 0.023, OR = 1.91, 95% CI: 1.09-3.33). The variant rs1881457(C) also significantly contributed to a nearly twofold risk of late-onset CAD (p(adj) = 0.024, OR = 1.93, 95% CI: 1.09-3.42). In conclusion, IL13 might be involved in CAD via different mechanisms under different conditions in the Chinese Han population.
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spelling pubmed-59064442018-04-30 IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population Zha, Ling-Feng Nie, Shao-Fang Chen, Qian-Wen Liao, Yu-Hua Zhang, Hong-Song Dong, Jiang-Tao Xie, Tian Wang, Fan Tang, Ting-Ting Xia, Ni Xu, Cheng-Qi Zhou, Ying-Chao Zeng, Zhi-Peng Jiao, Jiao Wang, Peng-Yun Wang, Qing K. Tu, Xin Cheng, Xiang Sci Rep Article Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole IL13 gene (i.e., rs1881457, rs2069744 and rs20541) and a two-stage cohort containing 1863 CAD cases and 1841 controls. Traditional risk factors for CAD, such as age, BMI, and other factors, were used as covariates in logistic regression analysis. In the total population, we found that two haplotypes of IL13 (ATG and ATA, ordered rs1881457(C)-rs2069744(T)-rs20541(A)) significantly contributed to the risk of CAD with adjusted p values less than 0.05 (p(adj) = 0.019 and p(adj) = 0.042, respectively). In subgroup population analyses, the variant rs1881457(C) was found to significantly contribute to a nearly two fold increase in the risk of CAD in men (p(adj) = 0.023, OR = 1.91, 95% CI: 1.09-3.33). The variant rs1881457(C) also significantly contributed to a nearly twofold risk of late-onset CAD (p(adj) = 0.024, OR = 1.93, 95% CI: 1.09-3.42). In conclusion, IL13 might be involved in CAD via different mechanisms under different conditions in the Chinese Han population. Nature Publishing Group UK 2018-04-18 /pmc/articles/PMC5906444/ /pubmed/29670225 http://dx.doi.org/10.1038/s41598-018-24592-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zha, Ling-Feng
Nie, Shao-Fang
Chen, Qian-Wen
Liao, Yu-Hua
Zhang, Hong-Song
Dong, Jiang-Tao
Xie, Tian
Wang, Fan
Tang, Ting-Ting
Xia, Ni
Xu, Cheng-Qi
Zhou, Ying-Chao
Zeng, Zhi-Peng
Jiao, Jiao
Wang, Peng-Yun
Wang, Qing K.
Tu, Xin
Cheng, Xiang
IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population
title IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population
title_full IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population
title_fullStr IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population
title_full_unstemmed IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population
title_short IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population
title_sort il-13 may be involved in the development of cad via different mechanisms under different conditions in a chinese han population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906444/
https://www.ncbi.nlm.nih.gov/pubmed/29670225
http://dx.doi.org/10.1038/s41598-018-24592-9
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