TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain

Although TRPV1 channels represent a key player of noxious heat sensation, the precise mechanisms for thermal hyperalgesia remain unknown. We report here that conditional knockout of deSUMOylation enzyme, SENP1, in mouse dorsal root ganglion (DRG) neurons exacerbated thermal hyperalgesia in both carr...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Gao, Yingwei, Tian, Quan, Deng, Qi, Wang, Yangbo, Zhou, Tian, Liu, Qiang, Mei, Kaidi, Wang, Yingping, Liu, Huiqing, Ma, Ruining, Ding, Yuqiang, Rong, Weifang, Cheng, Jinke, Yao, Jing, Xu, Tian-Le, Zhu, Michael X., Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906468/
https://www.ncbi.nlm.nih.gov/pubmed/29670121
http://dx.doi.org/10.1038/s41467-018-03974-7

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