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A computational model to predict the Diels–Alder reactivity of aryl/alkyl-substituted tetrazines
ABSTRACT: The tetrazine ligation is one of the fastest bioorthogonal ligations and plays a pivotal role in time-critical in vitro and in vivo applications. However, prediction of the reactivity of tetrazines in inverse electron demand Diels–Alder-initiated ligation reactions is not straight-forward....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Vienna
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906496/ https://www.ncbi.nlm.nih.gov/pubmed/29681659 http://dx.doi.org/10.1007/s00706-017-2110-x |