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Is There Evidence for a Rostral-Caudal Gradient in Fronto-Striatal Loops and What Role Does Dopamine Play?
Research has shown that the lateral prefrontal cortex (LPFC) may be hierarchically organized along a rostral-caudal functional gradient such that control processing becomes progressively more abstract from caudal to rostral frontal regions. Here, we briefly review the most recent functional MRI, neu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906550/ https://www.ncbi.nlm.nih.gov/pubmed/29706863 http://dx.doi.org/10.3389/fnins.2018.00242 |
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author | Vogelsang, David A. D'Esposito, Mark |
author_facet | Vogelsang, David A. D'Esposito, Mark |
author_sort | Vogelsang, David A. |
collection | PubMed |
description | Research has shown that the lateral prefrontal cortex (LPFC) may be hierarchically organized along a rostral-caudal functional gradient such that control processing becomes progressively more abstract from caudal to rostral frontal regions. Here, we briefly review the most recent functional MRI, neuropsychological, and electrophysiological evidence in support of a hierarchical LPFC organization. We extend these observations by discussing how such a rostral-caudal gradient may also exist in the striatum and how the dopaminergic system may play an important role in the hierarchical organization of fronto-striatal loops. There is evidence indicating that a rostral-caudal gradient of dopamine receptor density may exist in both frontal and striatal regions. Here we formulate the hypothesis that dopamine may be an important neuromodulator in hierarchical processing, whereby frontal and striatal regions that have higher dopamine receptor density may have a larger influence over regions that exhibit lower dopamine receptor density. We conclude by highlighting directions for future research that will help elucidating the role dopamine might play in hierarchical frontal-striatal interactions. |
format | Online Article Text |
id | pubmed-5906550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59065502018-04-27 Is There Evidence for a Rostral-Caudal Gradient in Fronto-Striatal Loops and What Role Does Dopamine Play? Vogelsang, David A. D'Esposito, Mark Front Neurosci Neuroscience Research has shown that the lateral prefrontal cortex (LPFC) may be hierarchically organized along a rostral-caudal functional gradient such that control processing becomes progressively more abstract from caudal to rostral frontal regions. Here, we briefly review the most recent functional MRI, neuropsychological, and electrophysiological evidence in support of a hierarchical LPFC organization. We extend these observations by discussing how such a rostral-caudal gradient may also exist in the striatum and how the dopaminergic system may play an important role in the hierarchical organization of fronto-striatal loops. There is evidence indicating that a rostral-caudal gradient of dopamine receptor density may exist in both frontal and striatal regions. Here we formulate the hypothesis that dopamine may be an important neuromodulator in hierarchical processing, whereby frontal and striatal regions that have higher dopamine receptor density may have a larger influence over regions that exhibit lower dopamine receptor density. We conclude by highlighting directions for future research that will help elucidating the role dopamine might play in hierarchical frontal-striatal interactions. Frontiers Media S.A. 2018-04-12 /pmc/articles/PMC5906550/ /pubmed/29706863 http://dx.doi.org/10.3389/fnins.2018.00242 Text en Copyright © 2018 Vogelsang and D'Esposito. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Vogelsang, David A. D'Esposito, Mark Is There Evidence for a Rostral-Caudal Gradient in Fronto-Striatal Loops and What Role Does Dopamine Play? |
title | Is There Evidence for a Rostral-Caudal Gradient in Fronto-Striatal Loops and What Role Does Dopamine Play? |
title_full | Is There Evidence for a Rostral-Caudal Gradient in Fronto-Striatal Loops and What Role Does Dopamine Play? |
title_fullStr | Is There Evidence for a Rostral-Caudal Gradient in Fronto-Striatal Loops and What Role Does Dopamine Play? |
title_full_unstemmed | Is There Evidence for a Rostral-Caudal Gradient in Fronto-Striatal Loops and What Role Does Dopamine Play? |
title_short | Is There Evidence for a Rostral-Caudal Gradient in Fronto-Striatal Loops and What Role Does Dopamine Play? |
title_sort | is there evidence for a rostral-caudal gradient in fronto-striatal loops and what role does dopamine play? |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906550/ https://www.ncbi.nlm.nih.gov/pubmed/29706863 http://dx.doi.org/10.3389/fnins.2018.00242 |
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