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Detection of functional protein domains by unbiased genome-wide forward genetic screening

Establishing genetic and chemo-genetic interactions has played key roles in elucidating mechanisms by which certain chemicals perturb cellular functions. In contrast to gene disruption/depletion strategies to identify mechanisms of drug resistance, searching for point-mutational genetic suppressors...

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Detalles Bibliográficos
Autores principales:	Herzog, Mareike, Puddu, Fabio, Coates, Julia, Geisler, Nicola, Forment, Josep V., Jackson, Stephen P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906580/ https://www.ncbi.nlm.nih.gov/pubmed/29670134 http://dx.doi.org/10.1038/s41598-018-24400-4

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