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Cutaneous lupus erythematosus in dogs: a comprehensive review

Since the first description of discoid lupus erythematosus (LE) in two dogs in 1979, the spectrum of canine cutaneous lupus erythematosus (CLE) variants has expanded markedly. In this review, we first propose an adaptation of the Gilliam-Sontheimer classification of CLE for dogs. We then review the...

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Autores principales: Olivry, Thierry, Linder, Keith E., Banovic, Frane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907183/
https://www.ncbi.nlm.nih.gov/pubmed/29669547
http://dx.doi.org/10.1186/s12917-018-1446-8
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author Olivry, Thierry
Linder, Keith E.
Banovic, Frane
author_facet Olivry, Thierry
Linder, Keith E.
Banovic, Frane
author_sort Olivry, Thierry
collection PubMed
description Since the first description of discoid lupus erythematosus (LE) in two dogs in 1979, the spectrum of canine cutaneous lupus erythematosus (CLE) variants has expanded markedly. In this review, we first propose an adaptation of the Gilliam-Sontheimer classification of CLE for dogs. We then review the signalment, clinical signs, laboratory and histopathology and treatment outcome of the currently recognized variants of canine CLE, which are vesicular CLE, exfoliative CLE, mucocutaneous LE and facial or generalized discoid LE. We end with a short description of the rare cutaneous manifestations of systemic LE in dogs. Canine CLE variants are heterogeneous, some of them mirror their human counterparts while others appear—thus far—unique to the dog. As most CLE subtypes seem to have a good prognosis after diagnosis, veterinarians are encouraged to become familiar with the spectrum of often-characteristic and unique clinical signs that would permit an early diagnosis and the rapid implementation of an effective treatment.
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spelling pubmed-59071832018-04-30 Cutaneous lupus erythematosus in dogs: a comprehensive review Olivry, Thierry Linder, Keith E. Banovic, Frane BMC Vet Res Review Since the first description of discoid lupus erythematosus (LE) in two dogs in 1979, the spectrum of canine cutaneous lupus erythematosus (CLE) variants has expanded markedly. In this review, we first propose an adaptation of the Gilliam-Sontheimer classification of CLE for dogs. We then review the signalment, clinical signs, laboratory and histopathology and treatment outcome of the currently recognized variants of canine CLE, which are vesicular CLE, exfoliative CLE, mucocutaneous LE and facial or generalized discoid LE. We end with a short description of the rare cutaneous manifestations of systemic LE in dogs. Canine CLE variants are heterogeneous, some of them mirror their human counterparts while others appear—thus far—unique to the dog. As most CLE subtypes seem to have a good prognosis after diagnosis, veterinarians are encouraged to become familiar with the spectrum of often-characteristic and unique clinical signs that would permit an early diagnosis and the rapid implementation of an effective treatment. BioMed Central 2018-04-18 /pmc/articles/PMC5907183/ /pubmed/29669547 http://dx.doi.org/10.1186/s12917-018-1446-8 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Olivry, Thierry
Linder, Keith E.
Banovic, Frane
Cutaneous lupus erythematosus in dogs: a comprehensive review
title Cutaneous lupus erythematosus in dogs: a comprehensive review
title_full Cutaneous lupus erythematosus in dogs: a comprehensive review
title_fullStr Cutaneous lupus erythematosus in dogs: a comprehensive review
title_full_unstemmed Cutaneous lupus erythematosus in dogs: a comprehensive review
title_short Cutaneous lupus erythematosus in dogs: a comprehensive review
title_sort cutaneous lupus erythematosus in dogs: a comprehensive review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907183/
https://www.ncbi.nlm.nih.gov/pubmed/29669547
http://dx.doi.org/10.1186/s12917-018-1446-8
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