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Ossabaw Pigs With a PCSK9 Gain‐of‐Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies

BACKGROUND: Ossabaw pigs are unique miniature swine with genetic predisposition to develop metabolic syndrome and coronary atherosclerosis after extended periods receiving atherogenic diets. We have hypothesized that transgenic Ossabaw swine expressing chimp PCSK9 (proprotein convertase subtilisin‐l...

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Detalles Bibliográficos
Autores principales:	Yuan, Fang, Guo, Liang, Park, Kyoung‐Ha, Woollard, John R., Taek‐Geun, Kwon, Jiang, Kai, Melkamu, Tamene, Zang, Bin, Smith, Samantha L., Fahrenkrug, Scott C., Kolodgie, Frank D., Lerman, Amir, Virmani, Renu, Lerman, Lilach O., Carlson, Daniel F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907533/ https://www.ncbi.nlm.nih.gov/pubmed/29572319 http://dx.doi.org/10.1161/JAHA.117.006207

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