Phosphatidylinositol 3‐Kinase–DNA Methyltransferase 1–miR‐1281–Histone Deacetylase 4 Regulatory Axis Mediates Platelet‐Derived Growth Factor–Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells

BACKGROUND: Platelet‐derived growth factor BB, a potent mitogen of pulmonary artery smooth muscle cells (PASMCs), has been implicated in pulmonary arterial remodeling, which is a key pathogenic feature of pulmonary arterial hypertension. Previous microRNA profiling in platelet‐derived growth factor...

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Detalles Bibliográficos
Autores principales: Li, Yanjiao, Li, Li, Qian, Zhengjiang, Lin, Boya, Chen, Jidong, Luo, Yixuan, Qu, Junle, Raj, J. Usha, Gou, Deming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907547/
https://www.ncbi.nlm.nih.gov/pubmed/29514810
http://dx.doi.org/10.1161/JAHA.117.007572

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