Cargando…
RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up
BACKGROUND: Remote ischemic preconditioning (RIPC) has been suggested to protect against certain forms of organ injury after cardiac surgery. Previously, we reported the main results of RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study, a multicenter trial randomizing 1403 cardiac s...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907591/ https://www.ncbi.nlm.nih.gov/pubmed/29581218 http://dx.doi.org/10.1161/JAHA.117.008077 |
_version_ | 1783315562397433856 |
---|---|
author | Meybohm, Patrick Kohlhaas, Madeline Stoppe, Christian Gruenewald, Matthias Renner, Jochen Bein, Berthold Albrecht, Martin Cremer, Jochen Coburn, Mark Schaelte, Gereon Boening, Andreas Niemann, Bernd Sander, Michael Roesner, Jan Kletzin, Frank Mutlak, Haitham Westphal, Sabine Laufenberg‐Feldmann, Rita Ferner, Marion Brandes, Ivo F. Bauer, Martin Stehr, Sebastian N. Kortgen, Andreas Wittmann, Maria Baumgarten, Georg Meyer‐Treschan, Tanja Kienbaum, Peter Heringlake, Matthias Schoen, Julika Treskatsch, Sascha Smul, Thorsten Wolwender, Ewa Schilling, Thomas Fuernau, Georg Bogatsch, Holger Brosteanu, Oana Hasenclever, Dirk Zacharowski, Kai |
author_facet | Meybohm, Patrick Kohlhaas, Madeline Stoppe, Christian Gruenewald, Matthias Renner, Jochen Bein, Berthold Albrecht, Martin Cremer, Jochen Coburn, Mark Schaelte, Gereon Boening, Andreas Niemann, Bernd Sander, Michael Roesner, Jan Kletzin, Frank Mutlak, Haitham Westphal, Sabine Laufenberg‐Feldmann, Rita Ferner, Marion Brandes, Ivo F. Bauer, Martin Stehr, Sebastian N. Kortgen, Andreas Wittmann, Maria Baumgarten, Georg Meyer‐Treschan, Tanja Kienbaum, Peter Heringlake, Matthias Schoen, Julika Treskatsch, Sascha Smul, Thorsten Wolwender, Ewa Schilling, Thomas Fuernau, Georg Bogatsch, Holger Brosteanu, Oana Hasenclever, Dirk Zacharowski, Kai |
author_sort | Meybohm, Patrick |
collection | PubMed |
description | BACKGROUND: Remote ischemic preconditioning (RIPC) has been suggested to protect against certain forms of organ injury after cardiac surgery. Previously, we reported the main results of RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study, a multicenter trial randomizing 1403 cardiac surgery patients receiving either RIPC or sham‐RIPC. METHODS AND RESULTS: In this follow‐up paper, we present 1‐year follow‐up of the composite primary end point and its individual components (all‐cause mortality, myocardial infarction, stroke and acute renal failure), in a sub‐group of patients, intraoperative myocardial dysfunction assessed by transesophageal echocardiography and the incidence of postoperative neurocognitive dysfunction 5 to 7 days and 3 months after surgery. RIPC neither showed any beneficial effect on the 1‐year composite primary end point (RIPC versus sham‐RIPC 16.4% versus 16.9%) and its individual components (all‐cause mortality [3.4% versus 2.5%], myocardial infarction [7.0% versus 9.4%], stroke [2.2% versus 3.1%], acute renal failure [7.0% versus 5.7%]) nor improved intraoperative myocardial dysfunction or incidence of postoperative neurocognitive dysfunction 5 to 7 days (67 [47.5%] versus 71 [53.8%] patients) and 3 months after surgery (17 [27.9%] versus 18 [27.7%] patients), respectively. CONCLUSIONS: Similar to our main study, RIPC had no effect on intraoperative myocardial dysfunction, neurocognitive function and long‐term outcome in cardiac surgery patients undergoing propofol anesthesia. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01067703. |
format | Online Article Text |
id | pubmed-5907591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59075912018-05-01 RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up Meybohm, Patrick Kohlhaas, Madeline Stoppe, Christian Gruenewald, Matthias Renner, Jochen Bein, Berthold Albrecht, Martin Cremer, Jochen Coburn, Mark Schaelte, Gereon Boening, Andreas Niemann, Bernd Sander, Michael Roesner, Jan Kletzin, Frank Mutlak, Haitham Westphal, Sabine Laufenberg‐Feldmann, Rita Ferner, Marion Brandes, Ivo F. Bauer, Martin Stehr, Sebastian N. Kortgen, Andreas Wittmann, Maria Baumgarten, Georg Meyer‐Treschan, Tanja Kienbaum, Peter Heringlake, Matthias Schoen, Julika Treskatsch, Sascha Smul, Thorsten Wolwender, Ewa Schilling, Thomas Fuernau, Georg Bogatsch, Holger Brosteanu, Oana Hasenclever, Dirk Zacharowski, Kai J Am Heart Assoc Original Research BACKGROUND: Remote ischemic preconditioning (RIPC) has been suggested to protect against certain forms of organ injury after cardiac surgery. Previously, we reported the main results of RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study, a multicenter trial randomizing 1403 cardiac surgery patients receiving either RIPC or sham‐RIPC. METHODS AND RESULTS: In this follow‐up paper, we present 1‐year follow‐up of the composite primary end point and its individual components (all‐cause mortality, myocardial infarction, stroke and acute renal failure), in a sub‐group of patients, intraoperative myocardial dysfunction assessed by transesophageal echocardiography and the incidence of postoperative neurocognitive dysfunction 5 to 7 days and 3 months after surgery. RIPC neither showed any beneficial effect on the 1‐year composite primary end point (RIPC versus sham‐RIPC 16.4% versus 16.9%) and its individual components (all‐cause mortality [3.4% versus 2.5%], myocardial infarction [7.0% versus 9.4%], stroke [2.2% versus 3.1%], acute renal failure [7.0% versus 5.7%]) nor improved intraoperative myocardial dysfunction or incidence of postoperative neurocognitive dysfunction 5 to 7 days (67 [47.5%] versus 71 [53.8%] patients) and 3 months after surgery (17 [27.9%] versus 18 [27.7%] patients), respectively. CONCLUSIONS: Similar to our main study, RIPC had no effect on intraoperative myocardial dysfunction, neurocognitive function and long‐term outcome in cardiac surgery patients undergoing propofol anesthesia. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01067703. John Wiley and Sons Inc. 2018-03-26 /pmc/articles/PMC5907591/ /pubmed/29581218 http://dx.doi.org/10.1161/JAHA.117.008077 Text en © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Meybohm, Patrick Kohlhaas, Madeline Stoppe, Christian Gruenewald, Matthias Renner, Jochen Bein, Berthold Albrecht, Martin Cremer, Jochen Coburn, Mark Schaelte, Gereon Boening, Andreas Niemann, Bernd Sander, Michael Roesner, Jan Kletzin, Frank Mutlak, Haitham Westphal, Sabine Laufenberg‐Feldmann, Rita Ferner, Marion Brandes, Ivo F. Bauer, Martin Stehr, Sebastian N. Kortgen, Andreas Wittmann, Maria Baumgarten, Georg Meyer‐Treschan, Tanja Kienbaum, Peter Heringlake, Matthias Schoen, Julika Treskatsch, Sascha Smul, Thorsten Wolwender, Ewa Schilling, Thomas Fuernau, Georg Bogatsch, Holger Brosteanu, Oana Hasenclever, Dirk Zacharowski, Kai RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up |
title | RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up |
title_full | RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up |
title_fullStr | RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up |
title_full_unstemmed | RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up |
title_short | RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up |
title_sort | ripheart (remote ischemic preconditioning for heart surgery) study: myocardial dysfunction, postoperative neurocognitive dysfunction, and 1 year follow‐up |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907591/ https://www.ncbi.nlm.nih.gov/pubmed/29581218 http://dx.doi.org/10.1161/JAHA.117.008077 |
work_keys_str_mv | AT meybohmpatrick ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT kohlhaasmadeline ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT stoppechristian ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT gruenewaldmatthias ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT rennerjochen ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT beinberthold ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT albrechtmartin ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT cremerjochen ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT coburnmark ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT schaeltegereon ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT boeningandreas ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT niemannbernd ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT sandermichael ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT roesnerjan ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT kletzinfrank ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT mutlakhaitham ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT westphalsabine ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT laufenbergfeldmannrita ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT fernermarion ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT brandesivof ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT bauermartin ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT stehrsebastiann ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT kortgenandreas ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT wittmannmaria ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT baumgartengeorg ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT meyertreschantanja ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT kienbaumpeter ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT heringlakematthias ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT schoenjulika ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT treskatschsascha ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT smulthorsten ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT wolwenderewa ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT schillingthomas ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT fuernaugeorg ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT bogatschholger ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT brosteanuoana ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT hasencleverdirk ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT zacharowskikai ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup AT ripheartremoteischemicpreconditioningforheartsurgerystudymyocardialdysfunctionpostoperativeneurocognitivedysfunctionand1yearfollowup |