PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS

Pancreatic duct adenocarcinoma was induced by intraductal administration of N‐ethyl‐N′‐nitro N‐nitrosoguanidine (ENNG) in two mongrel dogs. A dog received a total dose of 595 mg of ENNG during 12 months and was sacrificed. Duct obstruction was detected by pancreatography and duct adenocarcinoma was...

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Autores principales: Kamano, Toshiki, Azuma, Noboru, Katami, Atsuo, Tamura, Junji, Sakakibara, Noburu, Matsumoto, Michio, Mizumoto, Kazuhiro, Kitazawa, Shunji, Konishi, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907756/
https://www.ncbi.nlm.nih.gov/pubmed/3128497
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00001.x
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author Kamano, Toshiki
Azuma, Noboru
Katami, Atsuo
Tamura, Junji
Sakakibara, Noburu
Matsumoto, Michio
Mizumoto, Kazuhiro
Kitazawa, Shunji
Konishi, Yoichi
author_facet Kamano, Toshiki
Azuma, Noboru
Katami, Atsuo
Tamura, Junji
Sakakibara, Noburu
Matsumoto, Michio
Mizumoto, Kazuhiro
Kitazawa, Shunji
Konishi, Yoichi
author_sort Kamano, Toshiki
collection PubMed
description Pancreatic duct adenocarcinoma was induced by intraductal administration of N‐ethyl‐N′‐nitro N‐nitrosoguanidine (ENNG) in two mongrel dogs. A dog received a total dose of 595 mg of ENNG during 12 months and was sacrificed. Duct obstruction was detected by pancreatography and duct adenocarcinoma was found. Another dog was given a total dose of 350 mg of ENNG during 8 months and was sacrificed 26 months after the first administration of the carcinogen. Duct adenocarcinoma was found. No pancreatic tumors were found in 2 dogs given intraperitoneal N‐nitrosobis(2‐oxo‐propyl)amine at a total dose of 4000 mg or in 2 dogs given Tween 60 only. These results suggest that the direct presence of a carcinogen in the pancreatic duct was able to induce duct adenocarcinoma in dogs.
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spelling pubmed-59077562018-05-11 PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS Kamano, Toshiki Azuma, Noboru Katami, Atsuo Tamura, Junji Sakakibara, Noburu Matsumoto, Michio Mizumoto, Kazuhiro Kitazawa, Shunji Konishi, Yoichi Jpn J Cancer Res Rapid Communication Pancreatic duct adenocarcinoma was induced by intraductal administration of N‐ethyl‐N′‐nitro N‐nitrosoguanidine (ENNG) in two mongrel dogs. A dog received a total dose of 595 mg of ENNG during 12 months and was sacrificed. Duct obstruction was detected by pancreatography and duct adenocarcinoma was found. Another dog was given a total dose of 350 mg of ENNG during 8 months and was sacrificed 26 months after the first administration of the carcinogen. Duct adenocarcinoma was found. No pancreatic tumors were found in 2 dogs given intraperitoneal N‐nitrosobis(2‐oxo‐propyl)amine at a total dose of 4000 mg or in 2 dogs given Tween 60 only. These results suggest that the direct presence of a carcinogen in the pancreatic duct was able to induce duct adenocarcinoma in dogs. Blackwell Publishing Ltd 1988-01 /pmc/articles/PMC5907756/ /pubmed/3128497 http://dx.doi.org/10.1111/j.1349-7006.1988.tb00001.x Text en
spellingShingle Rapid Communication
Kamano, Toshiki
Azuma, Noboru
Katami, Atsuo
Tamura, Junji
Sakakibara, Noburu
Matsumoto, Michio
Mizumoto, Kazuhiro
Kitazawa, Shunji
Konishi, Yoichi
PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS
title PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS
title_full PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS
title_fullStr PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS
title_full_unstemmed PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS
title_short PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS
title_sort preliminary observation on pancreatic duct adenocarcinoma induced by intraductal administration of n‐ethyl‐n′ ‐nitro‐n‐nitrosoguanidine in dogs
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907756/
https://www.ncbi.nlm.nih.gov/pubmed/3128497
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00001.x
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