GALLIUM CITRATE, A NEW SENSITIZER OF CELLS TO HYPERTHERMIA

The killing effects of heat were studied on cultured mammalian cells (L5178Y) pre‐incubated with gallium (Ga) citrate, which is a popular tumor‐imaging diagnostic agent. The cells showed higher sensitivity to heat when they were pre‐incubated with Ga‐citrate. The pre‐incubated cells showed decreased...

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Detalles Bibliográficos
Autores principales: Shinohara, Kunio, Kawakami, Noriko, Kugotani, Maho, Nakano, Hisako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907758/
https://www.ncbi.nlm.nih.gov/pubmed/3128502
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00006.x
Descripción
Sumario:The killing effects of heat were studied on cultured mammalian cells (L5178Y) pre‐incubated with gallium (Ga) citrate, which is a popular tumor‐imaging diagnostic agent. The cells showed higher sensitivity to heat when they were pre‐incubated with Ga‐citrate. The pre‐incubated cells showed decreased ATP levels, and this may be responsible for the heat‐sensitizing effect.

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