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Development of an in vitro PIG-A gene mutation assay in human cells

Mutagens can be carcinogens, and traditionally, they have been identified in vitro using the Salmonella ‘Ames’ reverse mutation assay. However, prokaryotic DNA packaging, replication and repair systems are mechanistically very different to those in the humans we inevitably seek to protect. Therefore...

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Detalles Bibliográficos
Autores principales:	Rees, Benjamin J, Tate, Matthew, Lynch, Anthony M, Thornton, Catherine A, Jenkins, Gareth J, Walmsley, Richard M, Johnson, George E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Original Manuscripts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907909/ https://www.ncbi.nlm.nih.gov/pubmed/28057708 http://dx.doi.org/10.1093/mutage/gew059

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