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FGF1 improves functional recovery through inducing PRDX1 to regulate autophagy and anti‐ROS after spinal cord injury

Fibroblast growth factor 1 (FGF1) is thought to exert protective and regenerative effects on neurons following spinal cord injury (SCI), although the mechanism of these effects is not well understood. The use of FGF1 as a therapeutic agent is limited by its lack of physicochemical stability and its...

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Autores principales: Li, Jiawei, Wang, Qingqing, Cai, Hanxiao, He, Zili, Wang, Haoli, Chen, Jian, Zheng, Zengming, Yin, Jiayu, Liao, Zhiyong, Xu, Huazi, Xiao, Jian, Gong, Fanghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908106/
https://www.ncbi.nlm.nih.gov/pubmed/29512938
http://dx.doi.org/10.1111/jcmm.13566
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author Li, Jiawei
Wang, Qingqing
Cai, Hanxiao
He, Zili
Wang, Haoli
Chen, Jian
Zheng, Zengming
Yin, Jiayu
Liao, Zhiyong
Xu, Huazi
Xiao, Jian
Gong, Fanghua
author_facet Li, Jiawei
Wang, Qingqing
Cai, Hanxiao
He, Zili
Wang, Haoli
Chen, Jian
Zheng, Zengming
Yin, Jiayu
Liao, Zhiyong
Xu, Huazi
Xiao, Jian
Gong, Fanghua
author_sort Li, Jiawei
collection PubMed
description Fibroblast growth factor 1 (FGF1) is thought to exert protective and regenerative effects on neurons following spinal cord injury (SCI), although the mechanism of these effects is not well understood. The use of FGF1 as a therapeutic agent is limited by its lack of physicochemical stability and its limited capacity to cross the blood‐spinal cord barrier. Here, we demonstrated that overexpression of FGF1 in spinal cord following SCI significantly reduced tissue loss, protected neurons in the ventricornu, ameliorated pathological morphology of the lesion, dramatically improved tissue recovery via neuroprotection, and promoted axonal regeneration and remyelination both in vivo and in vivo. In addition, the autophagy and the expression levels of PRDX1 (an antioxidant protein) were induced by AAV‐FGF1 in PC12 cells after H(2)O(2) treatment. Furthermore, the autophagy levels were not changed in PRDX1‐suppressing cells that were treated by AAV‐FGF1. Taken together, these results suggest that FGF1 improves functional recovery mainly through inducing PRDX1 expression to increase autophagy and anti‐ROS activity after SCI.
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spelling pubmed-59081062018-05-03 FGF1 improves functional recovery through inducing PRDX1 to regulate autophagy and anti‐ROS after spinal cord injury Li, Jiawei Wang, Qingqing Cai, Hanxiao He, Zili Wang, Haoli Chen, Jian Zheng, Zengming Yin, Jiayu Liao, Zhiyong Xu, Huazi Xiao, Jian Gong, Fanghua J Cell Mol Med Original Articles Fibroblast growth factor 1 (FGF1) is thought to exert protective and regenerative effects on neurons following spinal cord injury (SCI), although the mechanism of these effects is not well understood. The use of FGF1 as a therapeutic agent is limited by its lack of physicochemical stability and its limited capacity to cross the blood‐spinal cord barrier. Here, we demonstrated that overexpression of FGF1 in spinal cord following SCI significantly reduced tissue loss, protected neurons in the ventricornu, ameliorated pathological morphology of the lesion, dramatically improved tissue recovery via neuroprotection, and promoted axonal regeneration and remyelination both in vivo and in vivo. In addition, the autophagy and the expression levels of PRDX1 (an antioxidant protein) were induced by AAV‐FGF1 in PC12 cells after H(2)O(2) treatment. Furthermore, the autophagy levels were not changed in PRDX1‐suppressing cells that were treated by AAV‐FGF1. Taken together, these results suggest that FGF1 improves functional recovery mainly through inducing PRDX1 expression to increase autophagy and anti‐ROS activity after SCI. John Wiley and Sons Inc. 2018-03-07 2018-05 /pmc/articles/PMC5908106/ /pubmed/29512938 http://dx.doi.org/10.1111/jcmm.13566 Text en © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Li, Jiawei
Wang, Qingqing
Cai, Hanxiao
He, Zili
Wang, Haoli
Chen, Jian
Zheng, Zengming
Yin, Jiayu
Liao, Zhiyong
Xu, Huazi
Xiao, Jian
Gong, Fanghua
FGF1 improves functional recovery through inducing PRDX1 to regulate autophagy and anti‐ROS after spinal cord injury
title FGF1 improves functional recovery through inducing PRDX1 to regulate autophagy and anti‐ROS after spinal cord injury
title_full FGF1 improves functional recovery through inducing PRDX1 to regulate autophagy and anti‐ROS after spinal cord injury
title_fullStr FGF1 improves functional recovery through inducing PRDX1 to regulate autophagy and anti‐ROS after spinal cord injury
title_full_unstemmed FGF1 improves functional recovery through inducing PRDX1 to regulate autophagy and anti‐ROS after spinal cord injury
title_short FGF1 improves functional recovery through inducing PRDX1 to regulate autophagy and anti‐ROS after spinal cord injury
title_sort fgf1 improves functional recovery through inducing prdx1 to regulate autophagy and anti‐ros after spinal cord injury
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908106/
https://www.ncbi.nlm.nih.gov/pubmed/29512938
http://dx.doi.org/10.1111/jcmm.13566
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