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Impaired vibrotactile sense in children and adolescents with type 1 diabetes – Signs of peripheral neuropathy

OBJECTIVE: To investigate whether multi-frequency vibrometry can identify individuals with elevated vibration perception thresholds (VPTs), reflecting impaired vibrotactile sense, among children and adolescents with type 1 diabetes. METHODS: In 72 pediatric patients with type 1 diabetes, VPTs were e...

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Detalles Bibliográficos
Autores principales: Ising, Erik, Dahlin, Lars B., Elding Larsson, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908163/
https://www.ncbi.nlm.nih.gov/pubmed/29672623
http://dx.doi.org/10.1371/journal.pone.0196243
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author Ising, Erik
Dahlin, Lars B.
Elding Larsson, Helena
author_facet Ising, Erik
Dahlin, Lars B.
Elding Larsson, Helena
author_sort Ising, Erik
collection PubMed
description OBJECTIVE: To investigate whether multi-frequency vibrometry can identify individuals with elevated vibration perception thresholds (VPTs), reflecting impaired vibrotactile sense, among children and adolescents with type 1 diabetes. METHODS: In 72 pediatric patients with type 1 diabetes, VPTs were evaluated for seven frequencies on two sites of the hand, and five frequencies on two sites of the foot. Z-scores, based on previously collected reference data, were calculated. Perception to light touch was investigated using monofilaments. Subjects’ characteristics were analyzed in comparison to normal and impaired vibrotactile sense. RESULTS: Subjects’ median age, disease duration and age at disease onset were 12.8, 5.3 and 6.9 years, respectively. A total of 13 out of 72 (18%) subjects had impaired vibrotactile sense on at least one foot site. Impaired vibrotactile sense was more common among subjects treated with multiple daily insulin injections (MDI) compared to subjects treated with continuous subcutaneous insulin infusion (CSII) (p = 0.013). Age at disease onset was higher among subjects with impaired vibrotactile sense (p = 0.046). No significant correlations were found with gender, HbA1c or duration of diabetes. CONCLUSIONS: Impaired vibrotactile sense, mirroring diabetic peripheral neuropathy, was found in 1/5 of the children and adolescents in the study, and was more common in patients treated with MDI than in subjects treated with CSII.
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spelling pubmed-59081632018-05-06 Impaired vibrotactile sense in children and adolescents with type 1 diabetes – Signs of peripheral neuropathy Ising, Erik Dahlin, Lars B. Elding Larsson, Helena PLoS One Research Article OBJECTIVE: To investigate whether multi-frequency vibrometry can identify individuals with elevated vibration perception thresholds (VPTs), reflecting impaired vibrotactile sense, among children and adolescents with type 1 diabetes. METHODS: In 72 pediatric patients with type 1 diabetes, VPTs were evaluated for seven frequencies on two sites of the hand, and five frequencies on two sites of the foot. Z-scores, based on previously collected reference data, were calculated. Perception to light touch was investigated using monofilaments. Subjects’ characteristics were analyzed in comparison to normal and impaired vibrotactile sense. RESULTS: Subjects’ median age, disease duration and age at disease onset were 12.8, 5.3 and 6.9 years, respectively. A total of 13 out of 72 (18%) subjects had impaired vibrotactile sense on at least one foot site. Impaired vibrotactile sense was more common among subjects treated with multiple daily insulin injections (MDI) compared to subjects treated with continuous subcutaneous insulin infusion (CSII) (p = 0.013). Age at disease onset was higher among subjects with impaired vibrotactile sense (p = 0.046). No significant correlations were found with gender, HbA1c or duration of diabetes. CONCLUSIONS: Impaired vibrotactile sense, mirroring diabetic peripheral neuropathy, was found in 1/5 of the children and adolescents in the study, and was more common in patients treated with MDI than in subjects treated with CSII. Public Library of Science 2018-04-19 /pmc/articles/PMC5908163/ /pubmed/29672623 http://dx.doi.org/10.1371/journal.pone.0196243 Text en © 2018 Ising et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ising, Erik
Dahlin, Lars B.
Elding Larsson, Helena
Impaired vibrotactile sense in children and adolescents with type 1 diabetes – Signs of peripheral neuropathy
title Impaired vibrotactile sense in children and adolescents with type 1 diabetes – Signs of peripheral neuropathy
title_full Impaired vibrotactile sense in children and adolescents with type 1 diabetes – Signs of peripheral neuropathy
title_fullStr Impaired vibrotactile sense in children and adolescents with type 1 diabetes – Signs of peripheral neuropathy
title_full_unstemmed Impaired vibrotactile sense in children and adolescents with type 1 diabetes – Signs of peripheral neuropathy
title_short Impaired vibrotactile sense in children and adolescents with type 1 diabetes – Signs of peripheral neuropathy
title_sort impaired vibrotactile sense in children and adolescents with type 1 diabetes – signs of peripheral neuropathy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908163/
https://www.ncbi.nlm.nih.gov/pubmed/29672623
http://dx.doi.org/10.1371/journal.pone.0196243
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