Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice

Mutations in the dentin sialophosphoprotein (DSPP) gene cause dentinogenesis imperfecta. After synthesis, DSPP is proteolytically processed into NH(2)- and COOH-terminal fragments. The NH(2)-terminal fragment of DSPP is highly glycosylated but not phosphorylated, whereas the COOH-terminal fragment (...

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Detalles Bibliográficos
Autores principales: Zhang, Hua, Xie, Xiaohua, Liu, Peihong, Liang, Tian, Lu, Yongbo, Qin, Chunlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908185/
https://www.ncbi.nlm.nih.gov/pubmed/29672573
http://dx.doi.org/10.1371/journal.pone.0195854

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