Small molecule CXCR4 antagonists block the HIV-1 Nef/CXCR4 axis and selectively initiate the apoptotic program in breast cancer cells

The chemokine receptor CXCR4 plays an integral role in the development of highly metastatic breast cancer and in the pathogenesis of chronic HIV infection. In this study, we compared the effects of CXCR4 antagonists on apoptosis induction in hematopoietic cells and in tumor cells. We incubated cells...

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Detalles Bibliográficos
Autores principales: Huang, Ming-Bo, Giesler, Kyle E., Katzman, Brooke M., Prosser, Anthony R., Truax, Valarie, Liotta, Dennis C., Wilson, Lawrence J., Bond, Vincent C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908301/
https://www.ncbi.nlm.nih.gov/pubmed/29682200
http://dx.doi.org/10.18632/oncotarget.24580

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