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Pharmacogenetics-based area-under-curve model can predict efficacy and adverse events from axitinib in individual patients with advanced renal cell carcinoma

We investigated the relationship between axitinib pharmacogenetics and clinical efficacy/adverse events in advanced renal cell carcinoma (RCC) and established a model to predict clinical efficacy and adverse events using pharmacokinetic and gene polymorphisms related to drug metabolism and efflux in...

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Detalles Bibliográficos
Autores principales:	Yamamoto, Yoshiaki, Tsunedomi, Ryouichi, Fujita, Yusuke, Otori, Toru, Ohba, Mitsuyoshi, Kawai, Yoshihisa, Hirata, Hiroshi, Matsumoto, Hiroaki, Haginaka, Jun, Suzuki, Shigeo, Dahiya, Rajvir, Hamamoto, Yoshihiko, Matsuyama, Kenji, Hazama, Shoichi, Nagano, Hiroaki, Matsuyama, Hideyasu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Clinical Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908314/ https://www.ncbi.nlm.nih.gov/pubmed/29682213 http://dx.doi.org/10.18632/oncotarget.24715

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