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Focused Ultrasound‐Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging‐Guided Brain Tumor Treatment

The blood brain barrier is the main obstacle to delivering diagnostic and therapeutic agents to the diseased sites of brain. It is still of great challenge for the combined use of focused ultrasound (FUS) and theranostic nanotechnology to achieve noninvasive and localized delivery of chemotherapeuti...

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Autores principales: Wu, Meiying, Chen, Wenting, Chen, Yu, Zhang, Haixian, Liu, Chengbo, Deng, Zhiting, Sheng, Zonghai, Chen, Jingqin, Liu, Xin, Yan, Fei, Zheng, Hairong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908350/
https://www.ncbi.nlm.nih.gov/pubmed/29721406
http://dx.doi.org/10.1002/advs.201700474
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author Wu, Meiying
Chen, Wenting
Chen, Yu
Zhang, Haixian
Liu, Chengbo
Deng, Zhiting
Sheng, Zonghai
Chen, Jingqin
Liu, Xin
Yan, Fei
Zheng, Hairong
author_facet Wu, Meiying
Chen, Wenting
Chen, Yu
Zhang, Haixian
Liu, Chengbo
Deng, Zhiting
Sheng, Zonghai
Chen, Jingqin
Liu, Xin
Yan, Fei
Zheng, Hairong
author_sort Wu, Meiying
collection PubMed
description The blood brain barrier is the main obstacle to delivering diagnostic and therapeutic agents to the diseased sites of brain. It is still of great challenge for the combined use of focused ultrasound (FUS) and theranostic nanotechnology to achieve noninvasive and localized delivery of chemotherapeutic drugs into orthotopic brain tumor. In this work, a unique theranostic nanoplatform for highly efficient photoacoustic imaging‐guided chemotherapy of brain tumor both in vitro and in vivo, which is based on the utilization of hollow mesoporous organosilica nanoparticles (HMONs) to integrate ultrasmall Cu(2−) (x)Se particles on the surface and doxorubicin inside the hollow interior, is synthesized. The developed multifunctional theranostic nanosystems exhibit tumor‐triggered programmed destruction due to the reducing microenvironment‐responsive cleavage of disulfide bonds that are incorporated into the framework of HMONs and linked between HMONs and Cu(2−) (x)Se, resulting in tumor‐specific biodegradation and on‐demand drug‐releasing behavior. Such tumor microenvironment‐responsive biodegradable and biocompatible theranostic nanosystems in combination with FUS provide a promising delivery nanoplatform with high performance for orthotopic brain tumor imaging and therapy.
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spelling pubmed-59083502018-05-02 Focused Ultrasound‐Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging‐Guided Brain Tumor Treatment Wu, Meiying Chen, Wenting Chen, Yu Zhang, Haixian Liu, Chengbo Deng, Zhiting Sheng, Zonghai Chen, Jingqin Liu, Xin Yan, Fei Zheng, Hairong Adv Sci (Weinh) Full Papers The blood brain barrier is the main obstacle to delivering diagnostic and therapeutic agents to the diseased sites of brain. It is still of great challenge for the combined use of focused ultrasound (FUS) and theranostic nanotechnology to achieve noninvasive and localized delivery of chemotherapeutic drugs into orthotopic brain tumor. In this work, a unique theranostic nanoplatform for highly efficient photoacoustic imaging‐guided chemotherapy of brain tumor both in vitro and in vivo, which is based on the utilization of hollow mesoporous organosilica nanoparticles (HMONs) to integrate ultrasmall Cu(2−) (x)Se particles on the surface and doxorubicin inside the hollow interior, is synthesized. The developed multifunctional theranostic nanosystems exhibit tumor‐triggered programmed destruction due to the reducing microenvironment‐responsive cleavage of disulfide bonds that are incorporated into the framework of HMONs and linked between HMONs and Cu(2−) (x)Se, resulting in tumor‐specific biodegradation and on‐demand drug‐releasing behavior. Such tumor microenvironment‐responsive biodegradable and biocompatible theranostic nanosystems in combination with FUS provide a promising delivery nanoplatform with high performance for orthotopic brain tumor imaging and therapy. John Wiley and Sons Inc. 2018-01-10 /pmc/articles/PMC5908350/ /pubmed/29721406 http://dx.doi.org/10.1002/advs.201700474 Text en © 2018 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Papers
Wu, Meiying
Chen, Wenting
Chen, Yu
Zhang, Haixian
Liu, Chengbo
Deng, Zhiting
Sheng, Zonghai
Chen, Jingqin
Liu, Xin
Yan, Fei
Zheng, Hairong
Focused Ultrasound‐Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging‐Guided Brain Tumor Treatment
title Focused Ultrasound‐Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging‐Guided Brain Tumor Treatment
title_full Focused Ultrasound‐Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging‐Guided Brain Tumor Treatment
title_fullStr Focused Ultrasound‐Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging‐Guided Brain Tumor Treatment
title_full_unstemmed Focused Ultrasound‐Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging‐Guided Brain Tumor Treatment
title_short Focused Ultrasound‐Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging‐Guided Brain Tumor Treatment
title_sort focused ultrasound‐augmented delivery of biodegradable multifunctional nanoplatforms for imaging‐guided brain tumor treatment
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908350/
https://www.ncbi.nlm.nih.gov/pubmed/29721406
http://dx.doi.org/10.1002/advs.201700474
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