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Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum
Rhythmic theta frequency (~5–12 Hz) oscillations coordinate neuronal synchrony and higher frequency oscillations across the cortex. Spatial navigation and context-dependent episodic memories are represented in several interconnected regions including the hippocampal and entorhinal cortices, but the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908441/ https://www.ncbi.nlm.nih.gov/pubmed/29620525 http://dx.doi.org/10.7554/eLife.34395 |
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author | Viney, Tim James Salib, Minas Joshi, Abhilasha Unal, Gunes Berry, Naomi Somogyi, Peter |
author_facet | Viney, Tim James Salib, Minas Joshi, Abhilasha Unal, Gunes Berry, Naomi Somogyi, Peter |
author_sort | Viney, Tim James |
collection | PubMed |
description | Rhythmic theta frequency (~5–12 Hz) oscillations coordinate neuronal synchrony and higher frequency oscillations across the cortex. Spatial navigation and context-dependent episodic memories are represented in several interconnected regions including the hippocampal and entorhinal cortices, but the cellular mechanisms for their dynamic coupling remain to be defined. Using monosynaptically-restricted retrograde viral tracing in mice, we identified a subcortical GABAergic input from the medial septum that terminated in the entorhinal cortex, with collaterals innervating the dorsal presubiculum. Extracellularly recording and labeling GABAergic entorhinal-projecting neurons in awake behaving mice show that these subcortical neurons, named orchid cells, fire in long rhythmic bursts during immobility and locomotion. Orchid cells discharge near the peak of hippocampal and entorhinal theta oscillations, couple to entorhinal gamma oscillations, and target subpopulations of extra-hippocampal GABAergic interneurons. Thus, orchid cells are a specialized source of rhythmic subcortical GABAergic modulation of ‘upstream’ and ‘downstream’ cortico-cortical circuits involved in mnemonic functions. |
format | Online Article Text |
id | pubmed-5908441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59084412018-04-23 Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum Viney, Tim James Salib, Minas Joshi, Abhilasha Unal, Gunes Berry, Naomi Somogyi, Peter eLife Neuroscience Rhythmic theta frequency (~5–12 Hz) oscillations coordinate neuronal synchrony and higher frequency oscillations across the cortex. Spatial navigation and context-dependent episodic memories are represented in several interconnected regions including the hippocampal and entorhinal cortices, but the cellular mechanisms for their dynamic coupling remain to be defined. Using monosynaptically-restricted retrograde viral tracing in mice, we identified a subcortical GABAergic input from the medial septum that terminated in the entorhinal cortex, with collaterals innervating the dorsal presubiculum. Extracellularly recording and labeling GABAergic entorhinal-projecting neurons in awake behaving mice show that these subcortical neurons, named orchid cells, fire in long rhythmic bursts during immobility and locomotion. Orchid cells discharge near the peak of hippocampal and entorhinal theta oscillations, couple to entorhinal gamma oscillations, and target subpopulations of extra-hippocampal GABAergic interneurons. Thus, orchid cells are a specialized source of rhythmic subcortical GABAergic modulation of ‘upstream’ and ‘downstream’ cortico-cortical circuits involved in mnemonic functions. eLife Sciences Publications, Ltd 2018-04-05 /pmc/articles/PMC5908441/ /pubmed/29620525 http://dx.doi.org/10.7554/eLife.34395 Text en © 2018, Viney et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Viney, Tim James Salib, Minas Joshi, Abhilasha Unal, Gunes Berry, Naomi Somogyi, Peter Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum |
title | Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum |
title_full | Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum |
title_fullStr | Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum |
title_full_unstemmed | Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum |
title_short | Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum |
title_sort | shared rhythmic subcortical gabaergic input to the entorhinal cortex and presubiculum |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908441/ https://www.ncbi.nlm.nih.gov/pubmed/29620525 http://dx.doi.org/10.7554/eLife.34395 |
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